Amelogenesis imperfecta (AI) is an inherited disorder with alterations in the quality and/or quantity of the dental enamel, with widely varying phenotypes and genotypes. By definition, AI deformities are limited to conditions which selectively disrupt the amelogenesis process. In this research we found that all patients with rough hypoplastic AI had a moderate to severe malocclusion with increased vertical dimensions regardless of the presence or absence of the ENAM g.8344delG mutation.
Growth and development of orofacial region in child important influence on the changes of chewing cycle and is different from chewing in adults. With eruption of permanent teeth the chewing cycles are changed in children. During the period of mixed dentition the area of the chewing cycle in the frontal and sagittal plane is increased, the time of opening the mouth is extended, which affect the total time component of the chewing cycle.