Samples were tracked from the point of collection, processed at network laboratories and stored for deposit at National Institute for Diabetesand Digestive and Kidney Diseases (NIDDK) Central Repositories. Results of genetic analyses have identified many novel regions that affect susceptibility to type1 diabetes. T1DGC created a resource of data and samples that is accessible to the research community.
COBISS.SI-ID: 27647705
We report severely reduced IL-17F and IL-22 responses to Candida albicans antigens. Surprisingly, these reductions are strongly associated with neutralizing autoantibodies to IL-17F and IL-22. Our multicenter survey revealed neutralizing autoantibodies against IL-17A (41%), IL-17F (75%), and/ or IL-22 (91%) in >150 APECED patients. We conclude that IL-22 and IL-17F are key natural defenders against CMC and that the immunodeficiency underlying CMC in both patient groups has an autoimmune basis.
COBISS.SI-ID: 26737881