Repressors LexA and IscR inhibit expression of the colicin K gene, cka. iscR stabilizes lexA binding to operator sequences and provokes a delay in cka exčpression following DNA damage providing bacterial cells time to repair DNA damage.
COBISS.SI-ID: 2608719
Numerous mechanisms at the level of transcription and posttranscriptionally ensure that colicins are produced only in cells exposed to extreme stress such as DNA damage and starvation.
COBISS.SI-ID: 2687055
A conformational change in the LexA protein occurs upon DNA binding.
COBISS.SI-ID: 2368847
Due to appearance of resistance against colicins, combinations of five colicins are effective during antimicrobial therapy.
COBISS.SI-ID: 2484303
The prevalence of the tcpC gene is statistically significantly associated with Escherichia coli strains isolated from patients with extraintestinal infections.
COBISS.SI-ID: 2164303