In doctoral thesis Podobnik B. (mentor prof. Komel R.) arguments the targeted inhibition of a fungal cytochrome P450, CYP53A15, represents an alternative approach to finding treatments for fungal infections, which differs from conventional inhibition of ergosterol synthesis (CYP51 - 14 alfa-demethylase). She found that several naturally occurring antifungal phenolic compounds inhibit CYP53A15 from the opportune pathogenic fungus Cochliobolus lunatus. Synergistic antifungal activity was observed in the presence of benzoate, a widely used food preservative.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 253816832The aim of the lecture was to analyse cytochromes P450 from the fungus C. heterostrophus, a taxonomically related fungus with a known genome, in comparison to other dothideomycetes in the order Pleosporales with many important phytopathogens, on grains for example, in relation to already indentified cytochromes P450 from C. lunatus. Well annotated genome of Aspergillus nidulans was used as reference. Filamentous fungi possess numerous cytochromes P450 (usually over 100), these enzymes are crucial in pathways of endogenous metabolism, while others act in xenobiotic detoxification.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 4385306