The association of microneedles with electric pulses causing electroporation could result in an efficient and less painful delivery of drugs and DNA into the skin. Hollow conductive microneedles were used for (1) needlefree intradermal injection and (2) electric pulse application in order to achieve electric field in the superficial layers of the skin sufficient for electroporation. Effective injection of proteins into the skin was achieved, resulting in an immune response directed to the model antigen ovalbumin.
COBISS.SI-ID: 7847508
Increased interest exists for the use of impedance spectroscopy to measure skin properties in vivo. The aim of such measurements can either be to evaluate the hydration state of the skin, to detect diseased states such as skin cancer, or simply to gather data on skin tissue impedance to be used in theoretical studies. We observed substantial impedance changes over time, recorded during the course of the measurement. They are mostly due to skin deformation caused by the electrodes pressing against skin. The analysis showed that skin elasticity can be inferred from these temporal changes.
COBISS.SI-ID: 7699540