The use of electric pulses to increase cell membrane permeability – electroporation – has also been used on skin for (a) enhanced transdermal molecular delivery or (b) the delivery of drugs or DNA into viable skin cells. Based on finite element numerical method, we theoretically described skin electropermeabilization and the amount of heating in and around an electrically created pore in the stratum corneum (SC). With the model, we address both, electrical as well as thermal effects on skin tissue.
COBISS.SI-ID: 8282708
Electroporator is a generator of electric pulses that is used for permeabilization of cells. There are five major concepts of electroporation design. Capacitor discharge, square wave generator, and analog generator are used to generate classical electroporation pulses that are longer than microsecond. Further, pulse forming network and resonant charging generators are used to generate nanosecond electroporation pulses. Basic concepts and foreseeable future developments in electroporator design are presented in this article.
COBISS.SI-ID: 8504916