We conclude that apparently healthy middle-aged subjects already had endothelial dysfunction. We confirmed that a short (30 days) low-dose therapy with fluvastatin (10 mg) improved endothelial-dependent vasodilation of the brachial artery and also diminished the stiffness of common carotid artery. It is therefore obvious that the early functional and morphological properties of arterial wall are in the early phase still reversible. The results of the present study therefore represent a new, original approach to early prevention of cardiovascular disease.
E.01 National awardsCOBISS.SI-ID: 3349780
The incidence and prevalence of cardiovascular diseases exponentially increase with age. Functional changes in the vascular system include deterioration of the responsiveness of the vascular endothelium – endothelial dysfunction. This is followed by morphological changes, increased vessel wall stiffness and increased intima-media thickness. Assuming that age is an independent risk factor for cardiovascular events, researching possible ways to slow the aging process of the vascular system and affecting reversible changes to blood vessels is becoming a challenge.
B.04 Guest lecture