In the study the preventive cardiovascular effects of combination of statin (fluvastatin 10 mg daily) and angiotensin receptor blocker (valsartan 20 mg daily) at sub-therapeutic doses in middle aged healthy volunteers were examined. The flow mediated dilation of brachial artery, the stiffness of carotid artery, pulse wave velocity and total antioxidative status improved after 30 days of intervention. The described results confirmed our hypothesis of improvement of vascular function after 30 days of therapy of subtherapeuthic doses of selected drugs.
The central hemodynamics, reflected by central pressure wave forms and arterial stiffness, can provide new and better insight into the pathophysiology of cardiovascular disorders associated with ageing, hypertension, diabetes, as well as end-stage renal disease. The aim of this article is to provide the pathophysiology and predictive role for cardiovascular events of central pressure wave forms that are beyond peripheral blood pressure. Improvement of central blood pressure can result in reduction of cardiovascular events.