The aim of this study was to investigate whether 30 days low-dose fluvastatin treatment could improve and reverse these arterial changes that are primarily associated with ageing, in otherwise healthy middle-aged males. In conclusion, we found that subtherapeutic low-dose fluvastatin (10mg daily; 30 days) considerably improves and reverses early functional and morphological arterial wall impairments that are present in apparently healthy, middle-aged males.
Statins are recognised as the most effective lipid-lowering drugs. The main mechanism of action is the inhibition of 3-HMG-coenzyme A reductase, which is a key enzyme in the cholesterol synthesis pathway. Statins also have additional effects, known as pleiotropic effects, which are mostly due to the inhibition of the formation of non-steroidal isoprenoids. In the current article we review the pharmacological mechanisms of action, which contribute to the beneficial pleiotropic effects of statins.