In this study we showed that age-related arterial wall changes in middle-aged males are reversible and could be reduced by a low-dose (20 mg daily), short-term (30 days) valsartan intervention.
The results of the present study indicate that age-related arterial changes in middle-aged males can be reversed. Short-term treatment with a low-dose fluvastatin/valsartan combination resulted in a large and long lasting improvement of arterial function.
The aim of this study was to investigate whether 30 days low-dose fluvastatin treatment could improve and reverse these arterial changes that are primarily associated with ageing, in otherwise healthy middle-aged males. In conclusion, we found that subtherapeutic low-dose fluvastatin (10mg daily; 30 days) considerably improves and reverses early functional and morphological arterial wall impairments that are present in apparently healthy, middle-aged males.