Cathepsin B is a lysosomal enzyme thought to be involved in tumour cell invasion and metastasis. This study was designed to investigate the presence of a known leucine to valine mutation at position 26 (L26V) single nucleotide polymorphism (SNP) in the cathepsin B (CTSB) gene in a Slovenian Caucasian population, and to evaluate the association with risk of prostate adenocarcinoma (PCa). The VV genotype of the CTSB L26V SNP may indicate an increased risk for PCa and less differentiated cancer (higher Gleason score).
COBISS.SI-ID: 3455551
This retrospective study investigated tissue marker expression in prostate adenocarcinoma biopsy samples. Identifying mathematical model that would take into account the opposing nature of proliferation and apoptosis would be a useful adjunct for studying disease behaviour. A model was developed which combined staining intensity data for Bcl-2 and AgNOR, as markers of proliferation, and for p53, as a marker of apoptotis. The model significantly correlated with Gleason score, AJCC stage and serum PSA, whereas each tissue marker alone did not correlate with all these measures.
COBISS.SI-ID: 64405505