More than 2700 unrelated individuals from Europe, northern Africa and western Asia were analyzed for the marker M269, which defines the Y chromosome haplogroup R1b1b2. A total of 593 subjects belonging to this haplogroup were identified and further analyzed for two SNPs, U106 and U152, which define haplogroups R1b1b2g and R1b1b2h, respectively. These haplogroups showed quite different frequency distribution patterns within Europe, with frequency peaks in northern Europe (R1b1b2g) and northern Italy/France (R1b1b2h).
COBISS.SI-ID: 3699007
TMPRSS2-ERG fusion gene and PTEN gene deletion are important markers of neoplastic transformation in prostate cancer. The aim of the study was to evaluate their potential as prognostic factors for the disease progression. The TMPRSS2 fusion gene was present in 38% of cases and PTEN deletions were observed in 60% of samples. The increased presence of rearrangements corresponds with high malignancy of analyzed cases. However, the prognostic value of both markers for the progression of the disease in patients was insufficient.
COBISS.SI-ID: 3761215