Development of molecular genetics and in the last period rapid advancement of genomic thechnology enabled research towards molecular architecture of mammary gland related traits. A number of genetic markers, associated with functional mutations in candidate genes allows application of DNA polymorphisms in selection procedures leading to marker assisted selection. In addition to specific milk trait related genes, there is also an important field of research covering health traits and improvement of animal welfare and robustness. Combination of large amounts of data with bioinformatics tools opens a new approach in mammary gland biology research, which is heavily dependent on large amounts of data and enables efficient combination of different types of data for more profound analysis of biological problems. For practical animal breeding and veterinary medicine these new technologies offer for the first time the possibility to select directly for favourable genetic vaiants, rather for phenotypic traits which might be heavily biased by environmental factors.
B.04 Guest lectureCOBISS.SI-ID: 3104648
A a consequence of rapid methodological development in the field of genome analysis, we are faced with the situation where huge data sets are available, often in the public domain. However, their integration, establishment of biolgical networks and comprehensive interpretation still represent a challenge which just recently with the development of novel bioinformatics tools became a feasible task. Data integration and causual interconnection of different pieces of evidence can certainly deliver useful information also for practical animal breeding. Therefore, we here present a new, gene map based, approach for representastion and integration of different types of data related to lactation, which allows a new holistic approach to farm animal genome analysis.
B.04 Guest lectureCOBISS.SI-ID: 3055240
Primary culture of mammary gland derived epithelial cells enables study of metabolic, regulatory and signalling pathways in the mammary epithelium. taking into account the regenerative potential of mammary cells, they also enable study of developmental potential and its role in cancer development and progression. The presented systemhas also potential to raplace experiments which include infections of the mammary gland.
B.04 Guest lectureCOBISS.SI-ID: 3114632