Supervisorship (mentorship) of PhD candidates, young researchers. Young researcher Eva Kralj has successfully finished her postgraduate (doctoral) studies within time.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 271092224To gain the insight into the intracellular imatinib uptake in granulocytes a very reliable two-stage sample concentration procedure was devised and coupled with a sensitive ultra-high performance liquid chromatography tandem mass spectrometry. The method has been applied to blood samples of 13 CML patients treated with imatinib and all the measured intracellular drug concentrations were within the validated range.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 3536497The good bioavailability of imatinib is highly likely achieved by its active absorption from the intestine and its active elimination through the intestinal mucosa is mediated by a synergistic activity of organic cation transporter 1 in the basolateral membrane and the activity of two efflux proteins (P-glycoprotein and breast cancer resistant protein) in the apical membrane of enterocytes.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 3460465Imatinib, dasatinib and nilotinib are three tyrosine kinase inhibitors currently used to treat positive chronic myeloid leukemia (CML). The acquired mutations in the BCR-ABL1 kinase domain may contribute to resistance to tyrosine kinase inhibitors in CML patients.
B.04 Guest lecture
COBISS.SI-ID: 3315057