Hypokalaemic periodic paralysis is a rare dominantly inherited disorder, which in approximately 70% of cases results from mutation in the CACNA1S calcium channel gene. It presents clinically with attacks of flaccid limb muscle weakness. Multiple sclerosis (MS) is a more common inflammatory disease of the central nervous system characterized by episodic or progressive neurological disability. The case of a patient in whom exacerbations and remissions of both diseases were intermingled, is described. This resulted in some difficulty in diagnosing the disease that presented later. The chance of both diseases occurring together is therefore approximately 6 to 20 per 10^9. Such an association has only been rarely reported, but its possibility must be kept in mind, and the superficial phenotypic similarities must not delay the recognition and appropriate treatment of the disease that presents later.
COBISS.SI-ID: 28765401