During the international conference organized by CIPKEBIP Centre of Excellence, Acies Bio researcher Gregor Kosec gave an lecture, describing approaches used by the company for production of novel analogues of medicinally important polyketide compounds and for optimization of the producing organisms from the actinomycete group. Biosynthetic engineering approaches are extremely valuable for generating derivatives of natural products that cannot be obtained by classical semisynthetic methods. In the scope of the lecture, current activities and results of this project related to recombination mechanisms were also presented. The presented results attracted a lot of attention from the academic and industrial researchers, participating at the conference and represent a good basis for future collaborations of Acies Bio in industrial and basic research projects.
B.04 Guest lecture
COBISS.SI-ID: 4171384In 2013 dr. Hrvoje Petković held an invited lecture at one of the most important congresses in the field of industrial microbiology “Genetics of Industrial Microorganisms GIM2013, which gathers most prominent academic researchers from this field as well as most important companies in the field of biotechnology. In his lecture dr. Petković presented new results in the field of FK506 biosynthesis, focusing on supply of different substrates. In the scope of the lecture, partially results of this project related to recombination mechanisms were also presented.
B.04 Guest lecture
COBISS.SI-ID: 4288888In 2014 dr. Hrvoje Petković held an invited lecture at 6. Congress of Slovenia microbiological society, which gathers all Slovenian academic researchers from this field. In his lecture dr. Petković presented work of project group on preparation of mutants of the native and industrial high producing strain of Saccharapolyspora erythraea with inactivated and overexpressed regulatory gene SACE_5599, which have been generated based on the results obtained in WP3 and better understanding of homologous recombination. Inactivation of SACE_5599 in the high-producing strain significantly reduced erythromycin yield, in addition to drastically decreasing sporulation intensity. In contrast, overexpression of SACE_5599 in the wild type NRRL23338 strain resulted in an increase of erythromycin yield by 32%, suggesting a very close relationship between secondary metabolite biosynthesis and morphological differentiation in this organism.
B.04 Guest lecture
COBISS.SI-ID: 3211343