The potential of supercritical (SC) CO2 as solvent or plasticizer for the processing of polymeric materials is reviewed in this study. The results suggest that SC CO2 due to its excellent properties, good solubility and plasticizing effect in polymers can be successfully used in processing biomaterials.
The work presents a review of the studies involving processing of polylactide, poly(lactide-co-glycolide) and their composites by using supercritical carbon dioxide in order to obtain structures with potential biomedical application.
Polyphenol antioxidants decrease the risk of atherosclerosis. The study aimed to evaluate prospectively in healthy young participants the effect of oral rosemary extracts (RE), consisting of diphenols, upon endothelial dysfunction (ED), preceding structural atherosclerosis. Nineteen healthy young volunteers were studied prospectively, who received oral RE (77.7 mg) for 21 days, consisting of active substances carnosol (0.97 mg), carnosic (8.60 mg) and rosmarinic acid (10.30 mg). Before and after RE treatment, the study evaluated fasting serum levels of plasminogen-activator-inhibitor-1 (PAI-1), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), superoxide dismutase (SOD), glutathione peroxidase (GPX), fibrinogen, high-sensitivity capsular reactive protein (hs-CRP), tumor-necrosis factor alpha (TNF-alpha), the lipid profile and ED, characterized as flow-mediated dilatation (FMD) in the brachial artery of (4.5%, estimated by ultrasound measurements. After 21 days, any side effects were registered, the mean FMD increased nonsignificantly (6.51 +/- 5.96% vs 7.78 +/- 4.56%, p = 0.546) and ED decreased significantly (66.6% vs 16.6%, p = 0.040). Among the serum markers, only the mean PAI-1 level decreased significantly (4.25 +/- 1.46 U/mL vs 3.0 +/- 0.61 U/mL, p = 0.012) after 21-day RE supplementation. It is concluded that oral RE supplementation has the potential to improve serum PAI-1 activity and ED in young and healthy individuals.