The pharmacokinetics of abamectin (ABM) following a single subcutaneous administration of 200 micrograms per kilogram was evaluated in adult follow deer by following ABM concentration in blood plasma. The time course of ABM concentration was described by two-compartment model with first-order absorption. Abamectin peak plasma concentration of 120.7 +/- 33.2 ng/mL observed at 19.1 +/- 7.7 h (mean +/- SD). Half lives of the distribution and terminal phase were 17.2 and 119.3 h, respectively. Typical apparent clearence of the bioavaliable fraction (CL/F) was 0.795 L/h and was indenpendent of animal weight.
COBISS.SI-ID: 3295866