Prof.dr. Peter Korošec was a mentor for PhD thesis Importance of peanut recombinant allergens and basophil activation test in peanut sensitivity. In this PhD thesis we showed that high basophil sensitivity in BAT test is directly connected with anaphylaxis. Low CD-sens levels exclude posibility of anaphylaxis or even peanut allergy. Peanut recombinant allergens are important in peanut allergy. Especially rAra h 2 express important allergenicity and is related with major clinical symptoms. Higher rAra h 2 levels and additional peanut recombinant allergens rAra h1 and h 3 increase the likelihood of peanut allergy. rAra h 9 showed now allergenicity in our population. Homologus allergens Ara h 8 and Bet v 1 are important in birch allergy. If rAra h 2 concentration was ) 0,35 KE/L then peanut allergy is suggested. In case of additionaly elevated concentrations of rAra h 1 and h 3 we can avoid additional peanut chalenge test in 85 %, what we can consider in diagnostic algorithm. Almost completely we can avoid peanut challenge in case of negative BAT testing results.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 512499768Anaphylaxis is one of the emergency situations. All healthcare professionals have to be skilled in the treatment of a patient with anaphylaxis. Studies have shown that in many cases anaphylaxis is not recognized or is insufficiently treated. New guidelines stress greater emphasis on the central role of early treatment with adrenaline intramuscularly, correct (lying) position of the patient and the importance of measures to be taken at discharge, such as education of patient on recognition of anaphylaxis and self-treatment, including the use of an adrenaline autoinjector. The document is in accordance with the existing literature in this field including the guidelines of the European Academy of Allergology and Clinical Immunology (EAAC). The document was created through coordination between the representatives of the professional sections and clinics. Guidelines aim to reduce the variability of management of anaphylaxis.
C.02 Editorial board of a national monograph
COBISS.SI-ID: 31995865Prof.dr Peter Korošec has become an Editorial Board Member of Clinical and Experimental Allergy in 2015. JCR IF(2014) = 4.769.
C.06 Editorial board membership
Diagnosis of angioedema is established in the presence of clinical and laboratory criteria. Here we present our experience on what laboratory can offer to improve the diagnosis of hereditary (HAE) and acquired angioedema (AE), from complement factors determination to genetic testing. A useful screening test is the determination of complement factor C4, which is low in both HAE and AAE. There are three types of HAE, first two types are caused by mutations affecting the C1 inhibitor gene (C1-INH), SERPING1, resulting in either low levels of C1-INH (Type I HAE, reduced C1-INH concentration and activity), or by normal levels of ineffective C1-INH (Type II HAE, reduced only C1-INH activity). The third type of HAE is HAE with normal C1-IN (normal C1-INH and C4 levels), where exact mechanism remains unknown, however about 25% of these patients have a gain-of-function mutation on Factor XII gene (F12). To differentiate between HAE and AAE, C1q is determined, which is normal in HAE and reduced in AAE. For proper diagnosis of those conditions a tight cooperation between clinic and laboratory is needed and complex procedures should be performed only in specialized and expert laboratories.
B.04 Guest lecture
COBISS.SI-ID: 38023941Prof. Dr. Mitja Košnik organized the Golnik Symposium 2015 in cooperation with other program committee members. The Congress with international participation was held in Bled. The main topics of the Congress were pulmonology, oncology and allergology.
B.01 Organiser of a scientific meeting
COBISS.SI-ID: 3788308