1.

A multimodal histamine ligand for chromatographic purification of plasmid DNA

This paper describes a new monolithic support with a histamine ligand that can be used as a multimodal ion-exchange and hydrophobic support. An application for the plasmid DNA purification in one step is presented.

COBISS.SI-ID: 4263544

2.

Reversible entrapment of plasmid deoxyribonucleic acid on different chromatographic supports

A reversible entrapment of the OC form of plasmid DNA within the monolithic structure is described together with the presentation of the ways how to overcome these limitations.

COBISS.SI-ID: 2899451

3.

Single step plasmid DNA purification using methacrylate monolith bearing combination of ion-exchange and hydrophobic groups

A novel mixed-mode grafted monolithic chromatographic support containing ion-exchange and hydrophobic groups is presented. Preparation and characterization of the novel material is described and the application for the plasmid DNA isolation is discussed.

COBISS.SI-ID: 4199288

4.

Fast separation of large biomolecules using short monolithic columns

Theoretical considerations of the separation of large biomolecules under the conditions of a linear gradient elution on the monolithic chromatography media are presented and elaborated.

COBISS.SI-ID: 4263032

5.

Downstream processing and chromatography based analytical methods for production of vaccines, gene therapy vectors, and bacteriophages

The paper gives an overview on the virus particle production challenges and chromatography based analytical methods for efficient monitoring of the virus production, covering also methods developed in the programme.

COBISS.SI-ID: 4534648