Preliminary results of our project were presented as a poster by Ph.D. student Maša Sinreih at the 10th Meeting of the Slovenian Biochemical Society with International Participation in Ljubljana, September 15-18, 2013. We studied expression of genes encoding progesterone receptors (PRA and PRB). Our qPCR results revealed significantly lower levels of PRAB and PRB, 1.8 and 2.0-fold, respectively, in EC versus adjacent control endometrium. The ratio PRB: PRAB (i.e., PRA + PRB) was 0.01 in EC and in the adjacent control endometrium - which shows that PRA is the main isoform in these tissues. The decreased expression of PRA indicates lower protection of progesterone against growth-promoting effects of estrogens. When we stratified the samples according to their differentiation, there were lower PRAB and PRB mRNA levels only in the G2 and G3 EC versus the adjacent control endometrium. The menopausal status had no influence on PRAB expression.
B.06 Other
COBISS.SI-ID: 30828761