The present study aims at achieving effects of improved hydrophilicity and microorganism inhibition, which are rarely simultaneously present in wound dressings. Viscose fibers in their non-woven form were modified using two different pathways. Effects of a two-step procedure, i.e. alkaline or oxygen plasma treatment followed by the attachment of silver chloride nanoparticles were compared to a onestep procedure, i.e. ammonium plasma treatment, which results in both desired material characteristics simultaneously. The surface properties of untreated and differently modified cellulose samples were analyzed by Xray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), in vitro silver release, and hydrophilicity measurements. The treatment effect on antimicrobial activity was determined by the AATCC 100-1999 standard test. In light of the introduced wound dressing preparation procedures and the desired wound dressing characteristics, the effectiveness of the used procedures was evaluated. Antimicrobial activity was proven against all Gram negative bacteria, while the Gram positive bacteria survive the as-prepared samples. Hydrophilicity was proven to be excellent using both preparation procedures. The mentioned results prove the potential of the used procedures and encourage future developments toward the clinical proof of concept.
COBISS.SI-ID: 16864278
In this paper, the use of ultrathin cellulose supports as platform for the incorporation of analgesic drugs in wound dressings is proposed. As a model drug, diclofenac (DCF) is chosen, which is commonly used in pain easing medical treatments. The DCF containing cellulose films are prepared by mixing solutions of trimethylsilyl cellulose (DSSi:2.5) with DCF dissolved in THF. After depositing the material on a solid surface by spin-coating, the films are subjected to vapor-phase hydrolysis using 3 M HCl in order to achieve regeneration of cellulose. The release of DCF from these films over time is studied by UV-Vis. Upon deposition of additional layers of cellulose that do not contain DCF, the release from these films can be decelerated significantly. The release kinetics from these films is very similar to those of viscose fibers impregnated with DCF solutions. These studies indicate a potential use of cellulose thin films as model platform for viscose based wound dressings.
COBISS.SI-ID: 18297110
Polarization microscopy was used for evaluation of kinetics of diclofenac sorption in three different wound dressing materials. The sorption kinetics can be evaluated by radii change and intensity of the light traveling through the fiber. The most frequently used host materials for drugs in wound dressings are alginate, polyesters such as polyethylene terephthalate, and viscose. We studied sorption of diclofenac as an example drug. Effective, but rather simple in vitro simulation of diclofenac sorption gives insight into the applicability of the mentioned materials for development of wound healing materials.
COBISS.SI-ID: 17742358