The patent describes a new approach for the preparation of chiral halogenoalkanes by asymmetric hydrogenation of halogenoalkenes. Obtained halogenoalkanes are useful as intermediates in the synthesis of pharmaceutical active compounds. For example, alfa-halogeno boronic esters can be used for preparation of boronic acid and ester compounds, such as bortezomib.
F.32 International patentCOBISS.SI-ID: 1564764
This solution provides a new, simple, economical and environmentally benign highly enantioselective synthesis to optically active 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]-azepine. The object of the patent is to provide novel asymmetric, efficient chemical catalytic systems of reduction of styrene derivatives to introduce chiral center in sustainable ways. Attention is also focused on the important last stages, where improved closing reactions of final intermediates to 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]-azepine are presented.
F.32 International patentCOBISS.SI-ID: 1575516
This patent application relates to a self-microemulsifying drug delivery system for abiraterone or abiraterone acetate, drug that is used to treat prostatic cancer. Drug delivery system includes one fatty acid ester and at least one surfactant. The invention describes a method of preparing the self- microemulsifying drug delivery system.
F.32 International patentCOBISS.SI-ID: 1551452