Non-immunoglobulin (non-Ig) scaffolds are, in contrast to antibodies, require no post-translational modification and can be used in bacteria. 102 proteins have been specifically targeted by 139 different non-Ig scaffold binders. Selected antiinflammatory scaffolds will be expressed in lactobacteria and used for treatment of inflammatory bowel disease.
COBISS.SI-ID: 3851377
Lysosomal cysteine peptidases - cysteine cathepsins - are general intracellular protein-degrading enzymes that control also a variety of specific physiological processes. They can trigger irreversible events leading to signal transduction and activation of signaling pathways, resulting in cell survival and proliferation or cell death. In cancer cells, lysosomal cysteine peptidases are involved in multiple processes during malignant progression.
COBISS.SI-ID: 3908977
Anti-sense DNA d(GGCCCC)[sup] expansions are repeats in genes encoding proteins, involved in neurodegenerative disorders. Authors demonstrated molecular mechanism involving the repeats in neurodegeneration.
COBISS.SI-ID: 29086759
Cathepsin B been shown to be involved in cancer progression. We reported an established antibiotic nitroxoline as a potent and selective inhibitor of cathepsin and elucidated its anti-tumor properties in in vitro and in vivo tumor models. Nitroxoline significantly abrogated tumor growth, angiogenesis and metastasis in vivo in LPB fibrosarcoma and MMTV-PyMT breast cancer mouse models. Overall, our results designate nitroxoline as a promising drug candidate for anti-cancer treatment.
COBISS.SI-ID: 3834225
Protein FUS is important in pathogenesis in neurodegenerative disease ALS. Authors demonstrated that its transport to nucleus depends on the phosphorylation of C-terminal tyrosine, resulting in formation of deposits in the cytoplasm of neuronal cells.
COBISS.SI-ID: 29044263