The paper presents the possibility of using genome editing for conversion of less favorable alleles into a more favorable allels in the context of livestock selection programs. The procedure allows editing of multiple loci simultaneously and leaves no trace of intervention in the genome. This technology represents a significant challenge for accelerating the selection programs aiming to increase the frequency of desired phenotypes in domestic animals.
F.05 Ability to launch new technological development cycle
COBISS.SI-ID: 3865736Analysis of DNA present in very small amounts in groundwater allows the identification of genetic elements that are characteristic for Proteus sanguinus, and to facilitate the detection of this rare species, which is under natural conditions difficult to detect in a relatively large habitats.
F.27 Contribution to preserving/protecting natural and cultural heritage
COBISS.SI-ID: 40165933Silencing of tumor suppressor genes by DNA promoter hypermethylation is an early event in carcinogenesis and a potential target for personalized cancer treatment. Promoter methylation profiling of HNSCC using MS-MLPA identified ATM, TIMP3, RARB, DAPK1, CDH13, APC and IGSF4 as frequent epigenetic events. Observed findings permit the identification of the nature of the tumor but they don´t allow the differentiation according the tumor stage.
F.21 Development of new health/diagnostic methods/procedures
COBISS.SI-ID: 5792063In a TEDx lecture the author presented the genetic background of obesity and environmental reasons for its occurrence. He explained genetic predetermination for obesity and analyzed the regulatory mechanisms that control fat deposition and metabolism of energy.
B.04 Guest lecture
COBISS.SI-ID: 3864456The TV program explained the mechanism of genome editing technology and presented some examples of genes with large effects on phenotypic traits, which could by this method be modified in a way to cause drastic changes in the phenotype.
F.30 Professional assessment of the situation
COBISS.SI-ID: 4107386