Solution of the proteins folding problem is very important for drug research (Lek and Krka). Current attempts to design new drugs have been largely unsuccessful because receptors and ligands are flexible molecules. Correctly predicted three-dimensional structures of bio-molecular complexes will considerably reduce the cost of developing new drugs. We introduced new methods of high-resolution NMR and vibrational spectroscopy for biomolecules in Slovenia, which is important for solving various problems in pharmaceutical industry (Lek). The results of our work have been published in the high-ranking scientific journals, which promotes Slovenian science in the world. By developing new methods we contribute to knowledge in those fields of science, which are currently crucial for technological progress in the world and thus also in Slovenia.