Periodontal disease could be explained on the model of chronic infected wound, which represents a potential focal inflammation that in longer period of time causes pathological changes of different degrees on heart, liver and kidney among risk population of dogs.The results of our study imply that chronically infected wound in oral cavity not only influences the survival of teeth but also have an impact on development of some pathological changes in risk organs in dogs. Total antioxidant capacities in gingival crevicular fluid is related to the degree of severity of periodontal disease in dogs. This is likely the result of release of reactive oxygen species by activated phagocytes and fibroblasts in the inflamed periodontal tissues. The results of the study implicate that as an addition to scaling and root planning, local delivery of antioxidants might be beneficial for therapy of periodontitis in dogs. The success of topical treatment of oral mucosa lesions via application of a drug onto oral mucosa depends on the selection of a suitable active ingredient and an appropriate carrier, rate of penetration through the mucosa and residence times of the active ingredient in oral mucosa. The results of the study prove that the greatest and longest effects of the hyperemic drug after its single application are obtained when the drug is incorporated in multilamellar liposomes made from hydrogenated soy lecithin.