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Mednarodni projekti vir: SICRIS

Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells

Uredi
Raziskovalci (1)
št. Evidenčna št. Ime in priimek Razisk. področje Vloga Obdobje Štev. publikacij
1.  01463  dr. Danijel Kikelj  Farmacija  Vodja  2012 - 2016  566 
Organizacije (1)
št. Evidenčna št. Razisk. organizacija Kraj Matična številka Štev. publikacij
1.  0787  Univerza v Ljubljani, Fakulteta za farmacijo  Ljubljana  1626973  17.159 
Povzetek
This COST Action aims to unite researchers with expertise in rational drug design and the medicinal chemistry of synthetic and natural compounds with biomedical investigators dedicated to the understanding the mechanisms governing drug resistance in cancer stem cells. Cancer stem cells (CSC) are a subpopulation of cells within tumors that exhibit enhanced tumor-initiating attributes and are a major contributing factor to current cancer therapy failure. The CSC phenotypic state comprises distinct molecular and functional differences that underpin resistance to current treatments and the unique ability spread and to seed new tumors throughout the body. This insight necessitates an entirely new approach to cancer drug development to effectively target tumor CSCs. Through exchange of information, experience and expertise, researcher mobility and fostering new collaboration between chemistry and biology groups, the Action endeavours to develop new, effective methods for identifying novel compounds and drug candidates that target drug-resistant cancer stem cells.
Zahtevana je potrditev
Zgodovina ogledov
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