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Mednarodni projekti vir: SICRIS

GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network

Uredi
Raziskovalci (2)
št. Evidenčna št. Ime in priimek Razisk. področje Vloga Obdobje Štev. publikacij
1.  20214  dr. Nina Vardjan  Nevrobiologija  Raziskovalec  2013 - 2017  267 
2.  13334  dr. Milka Vrecl Fazarinc  Veterina  Raziskovalec  2013 - 2017  269 
Organizacije (1)
št. Evidenčna št. Razisk. organizacija Kraj Matična številka Štev. publikacij
1.  0406  Univerza v Ljubljani, Veterinarska fakulteta  Ljubljana  1627139  10.756 
Povzetek
G protein-coupled receptors (GPCRs) are the largest family of proteins involved in signal transduction across membranes and one of the most important pharmaceutical drug target classes. In the past five years, an unprecedented number of X-ray structures of GPCRs have been solved, affording us first peeks at the molecular details of their function. Based on these and forthcoming structures, this COST Action will bring together experts in a wide range of complementary methods to unravel details of the activation mechanism, ligand binding, and the effect of the membrane and other interaction partners on GPCRs. The information exchange that will be made possible by the COST Action will lead to innovative insights into mechanistic details of GPCR function. This will in turn give rise to novel effector molecules to be used as lead structures for drug development, offering valuable new opportunities for European pharmaceutical research and industry.
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