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Mednarodni projekti vir: SICRIS

Archive's tissues: improving molecular medicine research and clinical practice

Raziskovalci (1)
št. Evidenčna št. Ime in priimek Razisk. področje Vloga Obdobje Štev. publikacijŠtev. publikacij
1.  02127  dr. Nina Gale  Medicina  Vodja  2007 - 2010  400 
Organizacije (1)
št. Evidenčna št. Razisk. organizacija Kraj Matična številka Štev. publikacijŠtev. publikacij
1.  0381  Univerza v Ljubljani, Medicinska fakulteta  Ljubljana  1627066  45.192 
Nowadays, emerging capabilities are being introduced to a more personalized molecular approach in medicine with individual risk assessment and best suited care. An important tool for translational research in this field is the large number of human archive tissues (AT), with any kind of disease, stored in hospitals all over Europe. Tissues from biopsies or surgical therapy are fixed and paraffin embedded to obtain a histopathology diagnosis, and then stored in archives for many decades. We developed already the technology that allows molecular research at DNA and RNA level in paraffin embedded tissues, so that the findings can be evaluated in the proper context. These methods were first designed by European scientists. In this way it is easy to study lesions with long follow-up, rare diseases, viral persistence or molecular pattern of lesions with known therapy outcomes. There is the opportunity of an European Coordination Action in advanced genomics to improve and speed up clinical applications for health and also for R&D of European biotechnology companies.The objectives of this CA are: a) to prepare molecular methods validation and standardization for AT; b) dissemination of standardized methods for functional genomics at European level with good practice rules; c) prepare future perspectives at clinical, research and technology level; d) establish bioethics guidelines for utilization of human archive tissues in research; e) organize tissues banks for translational research; f) promote technology innovation and industrial collaboration. Expected results of the Action are integrating European molecular research with a faster dissemination and application of molecular methods in clinical practice, preparing the opportunity of new multicentric functional genomics research projects, stimulating technology innovation with industrial collaboration in the fields of gene expression analysis and proteomics...
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