The interaction of xenobiotics with biological systems

Toxicity and tolerability of xenobiotics (food, drugs and poisons) is one of the largest challenges of contemporary investigations in biomedicine. Interactions of xenobiotics and xenobiotics with physiological substrates of the body can modify the function of biological systems usually with unpredictable consequences. The proposal is divided into three subprojects. In the first subproject the efficacy and toxicity of herbal preparations (hemp, mushrooms, etc), medicinal preparations (drugs like diclofenac, opiates, complex medicinal materials) and toxins (ethanol, pesticides) on organ systems and organism will be investigated. The precise detection of xenobiotics mechanism of action is expected to be explained together with its safety in the population. In the second subproject interactions between bile acid derivatives, as promoters of biopermeation and activators of intracellular enzyme systems, and other xenobiotics will be investigated. Surveys will be performed on cell-lines, isolated organs and experimental animals. Results will be implemented in the development of new pharmaceutical formulations with enhanced pharmacodynamic properties and safer use. The third subproject will be dedicated to postmarketing studies of drugs in population. Particular attention will be put on antibacterials and the factors determing their dosing regimen. Use will be compared with microbiology, pharmacodynamics and pharmacokinetics influencing the proper dosing and the choice.