An integral study to identify the regional genetic and environmental risk factors for the common noncommunicable diseases in the human population of Serbia - INGEMA_S

The real challenge in Serbia is combating both vascular diseases and diabetes, being common diseases, both multigenic and multifactorial ones. Thus, we organized project as complex one with working groups divided by topics related to type of both disease and environmental exposure, followed by ethical and life style aspect too. The questions are: 1) if the environmental exposure is equal for individuals within some population group why they suffered different diseases or if they are from different population groups why frequency of same disease is different?, and b) if the genomic structure of certain either individuals or population groups is a very similar, why they suffered different diseases? To get the right answers for both questions, we have to achieve right data for both genomic structure and environmental exposure within chosen different local entities. By well organized systematical research of collaborators from different fields supported by modern technology (bio-, nano- and ICT), geneticists, cell biologists, clinicians, bioinformaticists, physicists, chemists, will apply their experience and the latest worldwide knowledge combining applied and basic research, with output including data bases, risk assessment, development of diagnostic and therapeutic tools, and better knowledge of gene-environment interaction. Principal users will be ministries of health and env. protection, some oil, mining, food and pharmaceutical companies.