Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds

The project involves the study of the optimal synthetic conditions, through structure and properties examination of organic compounds with some potential biological activity, using up-to-date spectroscopical, electrochemical and chromatographic methods. The examined compounds include: substituted pyridones, pyridine and pyrimidine derivatives, hydantoines, succinimides, uraciles, thiazoles, steroids, N- and N,N-substituted amides, alfa, beta-unsatureted carboxylic acids and oxaprozin derivatives. These compounds represent the structure units of many natural biologically active compounds, some of which also show pharmacological activity. By correlation of the kinetic, spectroscopic and chromatographic parameters with corresponding experimentally obtained activity parameters, the quantitative relationships will be established between chemical structure, reactivity, physical and chemical properties and biological activity of examined compounds, by QSAR and QSRR relationships. Special attention will be given to the study of immunomodulatory activity of the compounds which proved earlier to have biological activity. Based on the obtained results in this project the new models will be established, which will show which structural elements of examined compounds contribute to their biological activity and how structural changes influence the intensity of the biological activity.