Structure-properties relationships of natural and synthetic molecules and their metal complexes

The research within this project will include a systematic study of the influence of the composition and structure of various natural and synthesized molecules on their properties by using modern chromatographic and statistical methods. Based on certain physicochemical parameters of the predicted chemical and biological activity, synthesis of new ligands and their complexes with metals is planned in order to obtain biologically active compounds and new materials. Determination of in vitro cytotoxic and antioxidant activity is planned for the newly synthesized compounds which are potentially biologically active. The examination of the stability of the newly synthesized materials with certain piezoelectric and optical properties is planned with the aim of their further application. A study of protolitic equilibria in homogenous and heterogeneous aqueous systems is planned for systems with expected biological activity in order to determine acidity and other equilibrium constants of ligands and complexes. Finally, the applicability of the developed chromatographic and chemometric methods in determining correlation between structure and properties of a molecule will be tested on complex natural systems within "fingerprint" analysis.