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Projects
Molecular properties and modifications of some respiratory and nutritional allergens
Research activity
| Code | Science | Field |
|---|---|---|
| P004 | Natural sciences and mathematics | Biochemistry, Metabolism |
| P310 | Natural sciences and mathematics | Proteins, enzymology |
Keywords
digestibility, food allergy, immunomodulation, immunotherapy, pollen
Organisations (6) , Researchers (1)
0011 University of Belgrade, Faculty of Chemistry
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 03289 | Biochemistry, Metabolism | Head | 2011 - 2019 | 55 |
0018 University of Belgrade, Faculty of Medicine
0025 University of Belgrade, Faculty of Veterinary Medicine
0097 University of Belgrade, Institute for Biological Research "Siniša Stanković" - National Institute of the Republic of Serbia
0158 Institute of Virology, Vaccines and Sera Torlak
0257 Innovation Center, Faculty of Chemistry in Belgrade Ltd (IC)
Abstract
Background: Proteins of pollen and food are common elicitors of allergic diseases. Research aiming at characterization of allergens leads to improvement of diagnosis and therapy of allergic diseases. Both safety and nutritional properties of food can be increased by modifying the food proteins. Project objectives: Improving basic knowledge on molecular properties of respiratory allergens, such as linden pollen.Insight into digestibility and effects of various processing and bioprocessing methods on allergenicity and biological activity of nutritional allergens, such as peanut and dairy allergens. Developing methods, including chemical, physicochemical and enzymatic that can modify allergens thus influencing its biological activity and immunological properties. Methodology: Respiratory and nutritional allergens will be characterized both by biochemical and immunological methods. Effects of modifications on structure, immunogenicity, digestibility and allergenicity will be investigated biochemically and immunologically. Deliverables: - Improved diagnosis of allergy to tree pollens will be achieved by molecular characterization of linden pollen allergens and its cross-reactivity to other tree allergens. - New modified respiratory allergens with potential use in immunotherapy of allergic diseases - Knowledge on factors that can influence digestibility, allergenicity and biological activity of food allergens.