The development of new synthetic methods and their application in the synthesis of natural products and biologically active molecules

The planned research encompasses several topics, which can be classified into two main groups: A) The development of new synthetic methods, and B) Total syntheses of natural products and biologically active compounds. Methodological studies, within the first group (A), will include: 1) Organocatalyzed aldol reactions of structurally complex substrates (additions of functionalized proenolates to aldehyde acceptors possessing stereocenters and heteroatom substituents in the alpha-position); 2) Formation of carbon-carbon bonds using dual catalysis (a combination of organocatalysis and organotransition metal catalysis); 3) Allylation in aqueous conditions with highly functionalized allylic halides, and 4) Intramolecular Fischer indole synthesis. Within the second group (B), total syntheses of the following molecules are planned: 1) Oseltamivir phosphate (Tamiflu); 2) Structurally modified, water soluble Paclitaxel analogues; 3) Structural analogues of Abyssomicin; 4) Otteliones and their structural analogues, and 5) (+)-Allokainic acid and its derivatives. All synthesized compounds will be tested for biological activity.