Development and application of the advanced chromatographic and spectrometric methods in the analysis of xenobiotics and their degradation pathways in biotic and abiotic matrices

The project aim is to develop novel and advanced analytical techniques for determination of xenobiotics in the environment and human organism taken by food or medicines-herbal medicinal products. Organic and inorganic pollutants, as well active substances of medicines, including herbal medicines will be analyzed. Analytical techniques based on chromatography (UHPLC, HPLC), mass spectrometry (QqQ, Orbitrap, ion trap) and optical spectroscopy (GFAAS, ICP-AES, etc.) will be used to develop reliable methods for analysis of xenobiotics in biotic and abiotic samples, including foodstuffs and medicines. The methods will be used to study the xenobiotic degradation in the environment, their fate in living organisms during bioaccumulation, the interactions with active substances of medicaments and herbal medicines, the metabolic pathways and therapeutic effects. Besides the analytical methods, biological, biochemical and statistical ones will be also used in order to assess the health and environmental risks and to identify the pollution sources. Gained knowledge will be applied in food and pharmaceutical industry and for the environmental protection. The project results will be incorporated in 8 PhD thesis, published in international journals, presented during the conferences and at the official project site. Moreover, knowledge transfer activities include organization of thematic events, trainings and workshops. Two prominent researchers from abroad are included in the project team.