CLINICAL AND EPIDIEMIOLOGICAL STUDY OF ADVERSE EVENTS IN HOSPITAL PATIENTS

Investigations of the most frequent adverse events (AEs) will be conducted at the different departments of the Clinical Center of Serbia:1.nosocomial infections (NI) 2.AEs in inpatients having surgery 3. adverse drug reaction (ADR). 1.Aim: to determine the incidence of NI, possible risk factors, and the most frequent etiological agents and their resistance to antibiotics. All patients hospitalized at the adult surgical intensive care units will be monitored during one year for the development of the most frequent NIs ( bloodstream infections-BSI and ventilator-associated pneumonia - VAP). Within this cohort, a nested case-control study will be performed. Patients with BSI will be considered as case, and matched to one control subjects (without BSI). 2. The retrospective-prospective cohort study the serious AEs in inpatients having surgery will be conducted. In the retrospective study, the chart of patients undergoing surgery at digestive, orthopedic, and emergency surgery departments during previous year will be reviewed by trained nurses and young medical doctors in the first and by senior specialists in the second stage process. A prospective, follow up study at the same wards will be performed using the same structured questionnaire.3. Prospective observational cohort study will be conducted in the medical/surgical intensive care units and in some medical general care units. Adverse drug reactions will be identified in three ways. A pharmacist will review all ADRs.