Loading...
Projects
Regenerative and modulatory potential of adult stem cells
Research activity
| Code | Science | Field |
|---|---|---|
| B001 | Biomedical sciences | General biomedical sciences |
| B210 | Biomedical sciences | Histology, cytochemistry, histochemistry, tissue culture |
| B470 | Biomedical sciences | Physiology |
| B490 | Biomedical sciences | Haematology, extracellular fluids |
| B500 | Biomedical sciences | Immunology, serology, transplantation |
Keywords
stem cells, microenvironment, signaling, tissue regeneration, immunomodulation
Organisations (3) , Researchers (1)
0109 University of Belgrade, Institute for Medical Research - National Institute of the Republic of Serbia
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 08044 | Haematology, extracellular fluids | Head | 2011 - 2019 | 32 |
0015 University of Belgrade, Faculty of Dental Medicine
0018 University of Belgrade, Faculty of Medicine
Abstract
Biology and function of two main types of multipotent adult stem cells, hematopoietic stem cells (HSCs) and mesenchymal stromal/stem cells (MSCs) will be studied with aim to understand basic underlying mechanisms regarding their regenerative and modulatory potential for clinical and pharmacological applications. The first task will include isolation, characterization and functional examination of stem cells to be used in further studies. Next, the role, mode of action and signal-transducing mechanisms by which various regulatory molecules (IL-17,TGF-beta1,IL-6,?NF-alpha,caveolin-1) and environmental parameters (hypoxia) direct stem cells fate and function will be examined, regarding their maintenance, recruitment or differential behavior according to the specific tissue or organ requirements. We also expect to determine stem cells participation in tissue repair, with emphases on proinflammatory cytokine-(IL-6,IL-17,TNFalpha)-induced differentiation, anti-inflammatory and anti-fibrotic effects of MSCs and the regulation of endothelial-to-mesenchymal transition by endoglin and hypoxia. Considering modulation of immunohematopoietic responses research will mainly focus on MSCs-HSCs interplay, the influence of IL-17 on hematopoietic supporting activity of MSCs and MSC-induced immunosuppression occurring via soluble mediators. In final task feasibility of selected MSCs to be used for development of 3-D tissue cultures will be investigated in conjunction with biomaterial supports.