Clinical significance of dysfunctions of innate and adaptive immunity in immunoinflammatory and immunodeficiency diseases

In spite of investigations, pathogenesis of most immunoinflammatory diseases remains unelucidated. New studies indicate that defects of apoptotic cell clearance and dysfunction of innate immunity components are connected with the initiation of immune-mediated diseases. The goals of the study are: 1) To investigate parameters of innate (desoxyribonuclease I in sera and skin, complement pentraxins) and adaptive immunity (autoantibodies) in patients with systemic lupus erythematosus (SLE) 2) To study the influence of innate immunity components on serological and clinical characteristics of SLE 3) To study the clinical importance of specificity, avidity, isotype of antibodies and concentration of B lymphocyte stimulator (BlyS) in immunoinflammatory diseases (connective tissue, inflammatory bowel diseases, vasculitides) and immunodeficiencies (complement and immunoglobulin deficiencies). Expected results: 1)SLE patients more frequently have decreased innate immunity components 2)Components of innate immunity influence the concentration of antichromatin antibodies, SLE activity and prognosis 3)Determination of specificity, avidity, isotype of autoantibodies and BlyS concentration has important clinical implications in immunoinflammatory and immunodeficiency diseases. The elucidation of the clinical importance of parameters of innate and adaptive immunity would enable the timely diagnosis and adequate treatment of patients with immunoinflammatory diseases and immunodeficiencies.