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Projects
Molecular determinants of innate immunity in autoimmunity and tumorogenesis
Research activity
| Code | Science | Field |
|---|---|---|
| B200 | Biomedical sciences | Cytology, oncology, cancerology |
| B220 | Biomedical sciences | Genetics, cytogenetics |
| B500 | Biomedical sciences | Immunology, serology, transplantation |
Keywords
immunomodulation, tumors, Con A induced hepatitis, EAE, galectin 3, IL-33/ST2 axis
Organisations (2) , Researchers (5)
0073 University of Kragujevac, Faculty of Medical Sciences
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 07111 | Cytology, oncology, cancerology | Head | 2011 - 2019 | 136 | |
| 2. | 10881 | Medicine (human and vertebrates) | Researcher | 2011 - 2019 | 19 | |
| 3. | 11068 | Immunology, serology, transplantation | Researcher | 2013 - 2019 | 13 | |
| 4. | 07189 | Immunology, serology, transplantation | Researcher | 2011 - 2019 | 7 | |
| 5. | 07276 | Immunology, serology, transplantation | Researcher | 2011 - 2019 | 34 |
0018 University of Belgrade, Faculty of Medicine
Abstract
The aim of this project is to analyze novel cellular and molecular determinants of susceptibility to organ specific autoimmunity and growth and metastasis of experimental tumors. Specifically, using complementary in vivo and in vitro approaches, we will study: a) The role of IL33/ST2 axis in the induction and development of experimental autoimmune encephalomyelitis (EAE), Con A induced hepatitis and growth and metastasis of experimental mammary carcinoma. b) The role of galectin-3 in Con A induced hepatitis and in the development of experimental malignant melanoma and potential therapeutic effects of newly synthesized galectin-3 inhibitor in these conditions. Taken together, these 2 lines of investigation should contribute to the development of new approaches in the immunomodulation of autoimmune response and tumors with potential implications for new treatment of corresponding diseases in humans.