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Projects / Programmes source: ARIS

Elastazni alfa-1 proteinazni inhibitor, hipofosfatemija in citokini v zgodnji diagnostiki sepse novorojenčka (Slovene)

Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   

Code Science Field
B660  Biomedical sciences  Pediatrics 
B590  Biomedical sciences  Anaesthesiology, intensive care 
Keywords
Elastase alpha-1 proteinase inhibitor, hypophosphataemia, intracellular ATP, 2,3 DPG, IL-6, soluble receptors for IL-2, IL-8, procalcitonin, newborn, severe infection
Evaluation (rules)
source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  05273  PhD Janez Babnik  Human reproduction  Researcher  1996 - 2001  180 
2.  02148  PhD Metka Derganc  Human reproduction  Head  1996 - 2001  452 
3.  06756  PhD Štefan Grosek  Human reproduction  Researcher  1996 - 2001  637 
4.  01521  PhD Marija Gubina  Microbiology and immunology  Researcher  1999 - 2001  370 
5.  12445  MSc Gorazd Kalan  Human reproduction  Researcher  1999 - 2001  119 
6.  07792  Inka Lazar  Human reproduction  Researcher  1996 - 2001  56 
7.  10691  PhD Joško Osredkar  Human reproduction  Researcher  1999 - 2001  1,305 
8.  02179  PhD Janez Primožič  Human reproduction  Researcher  1996 - 2001  272 
9.  15443  MSc Alenka Sešek Briški  Metabolic and hormonal disorders  Researcher  1996 - 2001  102 
10.  07793  Ivan Vidmar  Human reproduction  Researcher  1998 - 2001  247 
11.  04890  PhD Branka Wraber  Microbiology and immunology  Researcher  1999 - 2001  266 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,699 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  47,545 
Abstract
In the project, diagnostic value of elastase alpha-1 proteinase inhibitor (E-A1PI), hypophosphataemia, intracellular adenosine triphoshate (ATP) and 2,3 diphoshoglycerate (2,3 DPG), cytokines IL-6 and soluble receptors for IL-2 for the early diagnosis of severe neonatal infection was studied and compared with routinely used laboratory tests C-reactive protein (CRP) and leukocyte count and differential. In the study of 58 critically ill newborns, presented as magisterial thesis, E-A1PI proved to be a more sensitive marker of infection than CRP , leukocyte count and differential ( E-A1PI sensitivity 82 %, vs. CRP 40% and % bands 38%), and increased to 94 % at second determination. In the second study of 46 critically ill newborns (magisterial thesis) IL-6 was also a more sensitive (sensit. 92.8%) marker of infection than CRP (sensit. 85%). Soluble receptors for IL-2, however, were less sensitive (71%) but more specific (63% vs. CRP 40%). The area under the curve in ROC analysis for IL-6 was 0.794, for CRP 0.765 and soluble receptors for IL-2 0.732. Hypophosphataemia was significantly more common in severe infection than in hyaline membrane disease (HMD) and was due to the increased urine excretion. In severe infection significantly lower concentration of intracellular ATP and higher compensatory intracellular 2,3 DPG was found in comparison with hyaline membrane disease. A pilot study of IL-8 and procalcitonin has begun indicating their clinical usefulness.
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