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Projects / Programmes source: ARIS

Diagnostic and prognostic markers and treatment of acute pancreatitis

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Research activity

Code Science Field Subfield
3.07.00  Medical sciences  Metabolic and hormonal disorders   

Code Science Field
B550  Biomedical sciences  Gastro-enterology 
Keywords
acute pancreatitis - diagnostic markers, acute pancreatitis - prognostic markers, acute pancreatitis - treatment, cathepsin B, cathepsin H
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (7)
no. Code Name and surname Research area Role Period No. of publications
1.  10066  PhD Borut Kocijančič  Medical sciences  Researcher  1998 - 1999  77 
2.  17903  Gorazd Kolar  Metabolic and hormonal disorders  Researcher  1998 - 1999  12 
3.  04648  PhD Janko Kos  Biotechnical sciences  Researcher  1998 - 1999  1,159 
4.  06394  Marta Krašovec  Pharmacy  Researcher  1998 - 1999  83 
5.  01546  PhD Igor Križman  Medical sciences  Head  1998 - 1999  144 
6.  08054  PhD Janja Polanec  Microbiology and immunology  Researcher  1998 - 1999  30 
7.  10067  MSc Srečko Štepec  Metabolic and hormonal disorders  Researcher  1998 - 1999  89 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0259  Krka, tovarna zdravil, d.d., Novo mesto (Slovene)  Novo mesto  5043611  3,800 
2.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,588 
Abstract
The objective of our study was to assess the value of pancreatitis-associated protein (PAP) markers for the clinical diagnosis and prognosis of acute pancreatitis. The method has not proved suitable for differentiating between severe and mild forms of pancreatitis. Since patients with severe acute pancreatitis are admitted to several medical institutions in Ljubljana, including the Peter Derzaj Hospital, ICU and Department of Gastroenterology, University Medical Centre Ljubljana, we failed to collect sera from an adequate number of such patients. Despite the insufficient information provided by our study other research groups have confirmed our thesis that PAP markers have only a limited value in clinical practice. The implementation of another important study investigating the penetration of antibiotics in the necrotic tissue of the pancreas was not possible because of technical problems: we failed to carry out routine endoscopic collection of pancreatic juice and US-guided biopsies. We still need to address the issue of cathepsin measurements in patients with acute pancreatitis. Cathepsin determinations done on a sufficiently large series of patients with severe acute pancreatitis would provide important information warranting publication in the world literature. This study would be completed in the year 1999.
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