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Projects / Programmes source: ARIS

Multifunctional bioactive coatings on different substrates for biomedical applications

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Research activity

Code Science Field Subfield
1.04.00  Natural sciences and mathematics  Chemistry   

Code Science Field
B000  Biomedical sciences   

Code Science Field
1.04  Natural Sciences  Chemical sciences 
Keywords
multilayer materials, multifunctional coatings, stainless steel, TiAlV, drug delivery, corrosion, interaction studies, artificial hip
Evaluation (rules)
source: COBISS
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (32)
no. Code Name and surname Research area Role Period No. of publications
1.  27593  PhD Sebastjan Bevc  Medical sciences  Researcher  2018 - 2021  728 
2.  25434  PhD Urban Bren  Natural sciences and mathematics  Researcher  2018 - 2021  339 
3.  30944  PhD Lidija Čuček  Engineering sciences and technologies  Researcher  2019 - 2020  415 
4.  28477  PhD Matjaž Finšgar  Natural sciences and mathematics  Head  2018 - 2021  362 
5.  04537  PhD Mladen Franko  Natural sciences and mathematics  Researcher  2018 - 2021  600 
6.  19753  PhD Lidija Fras Zemljič  Engineering sciences and technologies  Researcher  2018 - 2021  508 
7.  20420  PhD Lidija Gradišnik  Medical sciences  Researcher  2018 - 2021  279 
8.  24387  PhD Maša Islamčević Razboršek  Natural sciences and mathematics  Researcher  2018  153 
9.  02619  PhD Željko Knez  Engineering sciences and technologies  Researcher  2018 - 2021  1,999 
10.  31463  PhD Dorota Agnieszka Korte  Natural sciences and mathematics  Researcher  2018 - 2021  148 
11.  52364  Boštjan Krajnc    Technical associate  2018 - 2021  0 
12.  02053  PhD Ivan Krajnc  Medical sciences  Researcher  2018 - 2021  615 
13.  39302  Tjaša Kraševac Glaser  Engineering sciences and technologies  Researcher  2018  16 
14.  06005  PhD Zdravko Kravanja  Engineering sciences and technologies  Researcher  2019 - 2021  892 
15.  24332  PhD Manja Kurečič  Engineering sciences and technologies  Researcher  2018 - 2021  217 
16.  21984  MSc Nermina Leber  Engineering sciences and technologies  Technical associate  2021  17 
17.  54894  David Majer  Natural sciences and mathematics  Researcher  2020  24 
18.  35511  PhD Tinkara Mastnak  Natural sciences and mathematics  Researcher  2019 - 2021  19 
19.  30850  PhD Uroš Maver  Medical sciences  Researcher  2018 - 2021  430 
20.  50675  PhD Marko Milojević  Medical sciences  Junior researcher  2018 - 2021  52 
21.  38917  Barbara Petovar  Natural sciences and mathematics  Researcher  2018 - 2019  40 
22.  35476  PhD Olivija Plohl  Engineering sciences and technologies  Researcher  2020 - 2021  99 
23.  16340  PhD Uroš Potočnik  Medical sciences  Researcher  2018 - 2021  604 
24.  52327  Sanja Potrč  Engineering sciences and technologies  Junior researcher  2019  50 
25.  50950  Martin Rozman  Natural sciences and mathematics  Researcher  2018 - 2020  41 
26.  52911  Kristijan Skok  Medical sciences  Researcher  2019 - 2021  88 
27.  07814  PhD Karin Stana Kleinschek  Engineering sciences and technologies  Researcher  2018 - 2019  1,110 
28.  32141  PhD Janja Stergar  Natural sciences and mathematics  Researcher  2019 - 2021  112 
29.  10575  PhD Simona Strnad  Engineering sciences and technologies  Researcher  2018 - 2021  367 
30.  38409  Eva Španinger  Natural sciences and mathematics  Researcher  2019 - 2020  12 
31.  54489  Jernej Vajda  Medical sciences  Junior researcher  2020 - 2021  8 
32.  26203  PhD Tomaž Velnar  Medical sciences  Researcher  2018 - 2021  374 
Organisations (4)
no. Code Research organisation City Registration number No. of publications
1.  0794  University of Maribor, Faculty of Chemistry and Chemical Engineering  Maribor  5089638012  12,498 
2.  0795  University ob Maribor, Faculty of mechanical engineering  Maribor  5089638010  24,290 
3.  1540  University of Nova Gorica  Nova Gorica  5920884000  13,649 
4.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  16,086 
Abstract
As the world’s population increases and ages, there is a parallel increase in the number of necessary medical procedures concerning bone related injuries, i.e. artificial hip replacements. The proposed project is focused on the development of novel bioactive coatings on medical grade stainless steel that will improve biocompatibility, bioactivity, durability, and corrosion resistance of this material. Medical grade stainless steel is still an important and the cheapest base material for artificial hips. It will remain attractive and affordable for the next couple of decades, due to its favourable characteristics, in terms of material-human body compatibility. Together with the main partners in this project, we have recently obtained promising results in the proposed field of research. This was published as a preliminary study in the renowned journal Scientific Reports, where we were able to develop the analytical tools to characterize this type of coatings. This project will build directly on the foundation provided by the preliminary study, and lead to the design of a far more complex and systematic approach regarding the development of bioactive coatings on medical grade stainless steel with the emphasis on manipulation of interaction phenomena between all interacting components. In the proposed project, we will prove the applicability of the novel developed coatings in a simulated physiological environment. Currently ceramic-based artificial hips are significantly more expensive compared to medical grade stainless steel-based material. Considering the ageing population and the increasing incidence of bone related diseases at a younger age, our coatings will also reduce the possibility of repeated hip replacement surgical procedures by prolonging the shelf-life of the current artificial hip solutions. Due to anatomical and physiological limitations the hip replacement is possible to be repeated only once more. After development of such coatings we will perform a fundamental study to explain how these coatings work (e.g. adsorption/desorption phenomena, study the controlled release of drugs that will be a part of the developed coatings, schematically shown in Figure below) and interact with the physiological environment (on human derived cells). Moreover, we will investigate in detail how these novel coatings affect the corrosion of the medical grade stainless steel, and use this knowledge to design coatings that will improve the corrosion resistance of this material under physiological conditions. The designed coatings might also have high potential to be used with the other metallic systems for artificial hips.
Significance for science
The proposed project is in many ways innovative, building on and upgrading the existing knowledge, as well as providing completely novel solutions in regard of multifunctional coating preparation, achieving bioactivity and improved osteointegration of orthopaedic implants. Hitherto, to the best of our knowledge no similar systematic study has been published yet and therefore this work presents an original approach to a real and pressing scientific, clinical and industrial problem.   The scientific community will greatly benefit from such an approach and the generated knowledge, since we will provide a fully working platform capable to be used also for testing of other similar materials. The development of fundamental knowledge and the proposed inventions may even lead to new patents.   New knowledge will be directly transferred to bachelor, master and PhD students as well as to postdoctoral researchers. Some of the specific actions to be undertaken for the communication and dissemination are listed: i) participation at conferences and scientific meetings on the national, bilateral and international level related to the objectives of the present project, including a positive inclination towards disseminating the results to interested industrial partners, working in similar fields (medicine, chemistry, pharmacy and steel engineering), with whom we could jointly apply for future Horizon 2020 project (and others); ii) publication of scientific articles in highly ranked journals with a broad readership, as well as industrial related journals within the sectors that will be indirectly or consequently involved in the present project; iii) organizing workshops for the dissemination of the resulting technology with the participation of R&D centres from the business associations of the industrial sectors related to the project; iv) scientific networking in order to establish a broad scientific and business network in fields related to the project content.   In addition, the fundamental knowledge obtained in the course of the project will help to design and tune specific new natural substances for preparation of highly-functional surface coatings onto the most widely used materials for other medical devices, such as stents, as well as for other materials applicable in different human care and health segments. In addition, by usage of natural and sustainable raw materials, the strictest European Ecological and Safety Regulations will also be fulfilled.   Even though this is a fundamental kind of project, partners of the consortium are in contact with potential end-users, i.e. Slovenian stainless steel producers (Jesenice, Ravne, and Štore) and titanium-alloy producer Akrapovič. These companies are highly interested in new knowledge that will be developed in this project. Moreover, we are in close contact to Lima Corporate from Italy (international orthopaedic implant producer company) and they are also highly interested in products developed in the proposed project.
Significance for the country
The proposed project is in many ways innovative, building on and upgrading the existing knowledge, as well as providing completely novel solutions in regard of multifunctional coating preparation, achieving bioactivity and improved osteointegration of orthopaedic implants. Hitherto, to the best of our knowledge no similar systematic study has been published yet and therefore this work presents an original approach to a real and pressing scientific, clinical and industrial problem.   The scientific community will greatly benefit from such an approach and the generated knowledge, since we will provide a fully working platform capable to be used also for testing of other similar materials. The development of fundamental knowledge and the proposed inventions may even lead to new patents.   New knowledge will be directly transferred to bachelor, master and PhD students as well as to postdoctoral researchers. Some of the specific actions to be undertaken for the communication and dissemination are listed: i) participation at conferences and scientific meetings on the national, bilateral and international level related to the objectives of the present project, including a positive inclination towards disseminating the results to interested industrial partners, working in similar fields (medicine, chemistry, pharmacy and steel engineering), with whom we could jointly apply for future Horizon 2020 project (and others); ii) publication of scientific articles in highly ranked journals with a broad readership, as well as industrial related journals within the sectors that will be indirectly or consequently involved in the present project; iii) organizing workshops for the dissemination of the resulting technology with the participation of R&D centres from the business associations of the industrial sectors related to the project; iv) scientific networking in order to establish a broad scientific and business network in fields related to the project content.   In addition, the fundamental knowledge obtained in the course of the project will help to design and tune specific new natural substances for preparation of highly-functional surface coatings onto the most widely used materials for other medical devices, such as stents, as well as for other materials applicable in different human care and health segments. In addition, by usage of natural and sustainable raw materials, the strictest European Ecological and Safety Regulations will also be fulfilled.   Even though this is a fundamental kind of project, partners of the consortium are in contact with potential end-users, i.e. Slovenian stainless steel producers (Jesenice, Ravne, and Štore) and titanium-alloy producer Akrapovič. These companies are highly interested in new knowledge that will be developed in this project. Moreover, we are in close contact to Lima Corporate from Italy (international orthopaedic implant producer company) and they are also highly interested in products developed in the proposed project.
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