Loading...
Projects / Programmes source: ARIS

Search for early epigenetic biomarkers of obesity-associated clinical complications in the pediatric population.

Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   

Code Science Field
B220  Biomedical sciences  Genetics, cytogenetics 

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
Obesity, Methylation, Epigenetics, Insulin Resistance, Metabolic Syndrome, pediatric population, early biomarkers
Evaluation (rules)
source: COBISS
Researchers (19)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  13023  PhD Tadej Battelino  Medical sciences  Researcher  2018 - 2021 
2.  15657  PhD Maruša Debeljak  Oncology  Researcher  2018 - 2021 
3.  22251  Jurka Ferran    Technical associate  2018 - 2019 
4.  38332  Maja Ficko  Human reproduction  Technical associate  2018 - 2021 
5.  50313  Tamara Grgić  Human reproduction  Researcher  2018 - 2021 
6.  33344  PhD Marija Holcar  Natural sciences and mathematics  Researcher  2018 
7.  28512  PhD Tinka Hovnik  Medical sciences  Researcher  2018 - 2021 
8.  21358  PhD Primož Kotnik  Human reproduction  Researcher  2018 - 2021 
9.  32181  PhD Jernej Kovač  Medical sciences  Head  2018 - 2021 
10.  51510  Jasmina Luskovec    Technical associate  2018 - 2021 
11.  35406  PhD Daša Perko  Human reproduction  Researcher  2018 - 2021 
12.  31306  Žiga Iztok Remec  Human reproduction  Technical associate  2018 - 2021 
13.  14020  PhD Barbka Repič Lampret  Human reproduction  Researcher  2018 - 2021 
14.  37426  PhD Robert Šket  Human reproduction  Researcher  2018 - 2021 
15.  36427  PhD Andraž Šmon  Metabolic and hormonal disorders  Researcher  2018 - 2019 
16.  50622  PhD Urša Šuštar  Metabolic and hormonal disorders  Junior researcher  2018 - 2021 
17.  37490  PhD Tine Tesovnik  Human reproduction  Researcher  2018 - 2021 
18.  20253  PhD Katarina Trebušak Podkrajšek  Human reproduction  Researcher  2018 - 2021 
19.  23267  Mirjana Zupančič  Human reproduction  Researcher  2018 - 2020 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  125 
Abstract
Obesity in children and adolescents is one of the main public healthcare problems worldwide. Although it was recently shown that growing obesity trends stabilized it is still imperative to identify molecular mechanisms leading to the development of obesity associated clinical complications. The impaired sensitivity of tissues to insulin, especially liver, skeletal muscle and adipose tissue is considered the main metabolic complication of obesity. This pre-diabetic state is already present in obese children and adolescent. Genetic background has an important role in the development of both insulin resistance (IR) and type 2 diabetes (T2D). On top of that, it has been recently recognized that epigenetic information passed from parents to siblings may affect offspring’s metabolic status expanding the potential of inherited epigenetic information as an early biomarker of metabolic risk even before the main trigger (obesity in this case) affects the subject. The potential role of gene expression regulation in the development of clinical complications in obesity has been recently indirectly demonstrated by published results of our research team, where the specific gene variant located in the promoter region of gene DEPTOR has been associated with the risk of developing IR in obese pediatric patients. From the point of view of the public health and appropriate clinical management of the obese pediatric population it is crucial to identify the molecular background of obesity and its complications etiology. A clinical application of such a biomarker would positively affect the patient’s quality of life due to the improved clinical algorithms focused on prevention of IR and T2D. The proposed project’s hypothesis claims that it’s possible to identify specific epigenetic changes in the blood derived gDNA samples of obese children associated with the development of IR and metabolic syndrome potentially a consequence of prenatal, perinatal and/or early postnatal metabolic programming. The main focus of proposed project is the identification of DNA methylation patterns associated with IR, pre-diabetic state important for clinical intervention. The results of proposed project would be among the first to address the potential association between specific epigenetic changes and the risk of IR development in obese pediatric population.
Significance for science
Positive results of this project would improve the quality of clinical practice for the obese pediatric population at risk of developing insulin resistance and eventually type 2 diabetes. Moreover, the potential prevention of type 2 diabetes development would result in a reduced burden on public healthcare systems by reducing the costs of type 2 diabetes treatment. Additionally, the success of this project would bring another international recognition of the excellence generated by Slovenian (medical) science.
Significance for the country
Positive results of this project would improve the quality of clinical practice for the obese pediatric population at risk of developing insulin resistance and eventually type 2 diabetes. Moreover, the potential prevention of type 2 diabetes development would result in a reduced burden on public healthcare systems by reducing the costs of type 2 diabetes treatment. Additionally, the success of this project would bring another international recognition of the excellence generated by Slovenian (medical) science.
Most important scientific results Interim report
Most important socioeconomically and culturally relevant results Interim report
Views history
Favourite