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Projects / Programmes source: ARIS

Unravelling dynamics of potato virus Y-plant cell interaction network

Research activity

Code Science Field Subfield
1.03.04  Natural sciences and mathematics  Biology  Plant physiology 

Code Science Field
1.06  Natural Sciences  Biological sciences 
Keywords
potato, potato virus Y (PVY), PVY-plant interaction, spatiotemporal analysis, systems biology, structural analysis
Evaluation (rules)
source: COBISS
Points
6,450.59
A''
1,717.22
A'
3,955.84
A1/2
4,876.83
CI10
14,117
CImax
337
h10
54
A1
24.22
A3
14.45
Data for the last 5 years (citations for the last 10 years) on April 22, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender, archive )
Database Linked records Citations Pure citations Average pure citations
WoS  682  19,266  15,875  23.28 
Scopus  724  21,723  17,954  24.8 
Researchers (20)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  55978  Primož Bembič  Biochemistry and molecular biology  Technical associate  2021 - 2024 
2.  24290  PhD Matej Butala  Biochemistry and molecular biology  Researcher  2020 - 2024  236 
3.  34130  PhD Anna Coll Rius  Biochemistry and molecular biology  Head  2020 - 2024  163 
4.  12688  PhD Kristina Gruden  Biotechnology  Researcher  2020 - 2024  985 
5.  27827  PhD Jon Gutierrez Aguirre  Biotechnology  Researcher  2020 - 2024  363 
6.  53283  Maja Hostnik  Biochemistry and molecular biology  Researcher  2020 - 2024  18 
7.  51987  PhD Mojca Juteršek  Biotechnology  Junior researcher  2020 - 2022  42 
8.  50722  Luka Kavčič    Technical associate  2021 - 2024  29 
9.  38255  PhD Andreja Kežar  Biochemistry and molecular biology  Researcher  2020 - 2024  42 
10.  35382  PhD Matic Kisovec  Biochemistry and molecular biology  Researcher  2020 - 2024  80 
11.  36323  PhD Tjaša Lukan  Biology  Researcher  2020 - 2021  125 
12.  55449  Martina Mravinec  Biochemistry and molecular biology  Researcher  2021  11 
13.  39090  PhD Anastasija Panevska  Biochemistry and molecular biology  Junior researcher  2020  55 
14.  12048  PhD Marjetka Podobnik  Biochemistry and molecular biology  Researcher  2020 - 2024  316 
15.  05229  PhD Maja Ravnikar  Biotechnology  Researcher  2020 - 2024  1,369 
16.  15328  PhD Kristina Sepčić  Biochemistry and molecular biology  Researcher  2020 - 2024  729 
17.  29635  Katja Stare  Biology  Technical associate  2020 - 2024  86 
18.  50566  PhD Špela Tomaž  Biotechnology  Researcher  2020 - 2024  28 
19.  09864  PhD Magda Tušek Žnidarič  Biology  Technical associate  2020 - 2024  414 
20.  27522  PhD Anže Županič  Systems and cybernetics  Researcher  2020 - 2024  179 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0105  National Institute of Biology  Ljubljana  5055784  13,258 
2.  0104  National Institute of Chemistry  Ljubljana  5051592000  20,968 
3.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  66,306 
Abstract
Potato virus Y (PVY) is the most economically devastating plant virus affecting the potato production worldwide. To accomplish its infection cycle, which includes entry, translation, replication, cell-to-cell movement and encapsidation, the virus relies on the molecular machinery of the infected host cell. Each viral process engages several viral factors, both nucleic acid and/or proteins, and host plant proteins to ensure an optimal virus infection. Thus, within the infection cycle, a complex interacting network, which is dynamic in time and space, and includes viral and plant components, is established. To address the dynamic nature of the interaction, we need an innovative and interdisciplinary approach. We will combine structural analysis and in planta functional studies, using pull-down assay coupled to mass spectrometry and live cell imaging, to explore the interaction network of viral and host components involved in different stages of the PVY infection. The generated data, including novel interactions as well as additional kinetic and structural data, will be fed into a model of plant defence signalling. In summary, the proposed project will strongly provide a breakthrough in understanding the protein interactions that occur during the PVY infection and will shed light into the mechanism of action of this important virus, enabling new strategies of virus control. On the other hand, it will provide us with potential host targets for crop breeding programmes. In addition, the project will contribute to the field with new valuable research tools to monitor changes of the interactome established within other viral pathosystems. The extensive expertise that the involved partners, National Institute of Biology, National Institute of Chemistry and Biotechnology Faculty, have in PVY-plant interaction, molecular interactions, and protein structure, will ensure a successful outcome of the proposed project.
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