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Projects / Programmes source: ARIS

Biofunctionalization of 3D-Printed Metal Alloys as a Newly Emerging Strategy to Diminish Undesired Effects of Orthopedic Implants

Research activity

Code Science Field Subfield
1.04.00  Natural sciences and mathematics  Chemistry   

Code Science Field
1.04  Natural Sciences  Chemical sciences 
Keywords
3D-printed materials, biofunctionalized materials, stainless steel, TiAlV, CoCr, drug release, corrosion, materials characterization, interaction studies, orthopedic implants
Evaluation (rules)
source: COBISS
Researchers (25)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  25434  PhD Urban Bren  Chemistry  Researcher  2020 - 2023  368 
2.  54490  Laura Činč Ćurić  Pharmacy  Researcher  2021 - 2023  19 
3.  11943  PhD Igor Drstvenšek  Manufacturing technologies and systems  Researcher  2020 - 2023  549 
4.  28477  PhD Matjaž Finšgar  Chemistry  Head  2020 - 2023  412 
5.  04537  PhD Mladen Franko  Control and care of the environment  Researcher  2020 - 2023  608 
6.  50635  PhD Veronika Furlan  Chemistry  Researcher  2022 - 2023  31 
7.  20420  PhD Lidija Gradišnik  Neurobiology  Researcher  2020 - 2023  294 
8.  02619  PhD Željko Knez  Chemical engineering  Researcher  2020 - 2023  2,029 
9.  31463  PhD Dorota Agnieszka Korte  Control and care of the environment  Researcher  2020 - 2023  157 
10.  38220  PhD Urška Kostevšek Šegula  Manufacturing technologies and systems  Researcher  2020  23 
11.  21689  PhD Petra Kotnik  Chemical engineering  Researcher  2020 - 2023  155 
12.  06005  PhD Zdravko Kravanja  Chemical engineering  Researcher  2020 - 2023  905 
13.  35511  PhD Tinkara Mastnak  Chemistry  Researcher  2020 - 2022  19 
14.  33260  PhD Tina Maver  Medical sciences  Researcher  2021 - 2023  179 
15.  30850  PhD Uroš Maver  Medical sciences  Researcher  2020 - 2023  455 
16.  50675  PhD Marko Milojević  Metabolic and hormonal disorders  Researcher  2020 - 2021  60 
17.  52595  Azra Osmić  Chemistry  Technical associate  2022 - 2023  14 
18.  52556  PhD Snehashis Pal  Chemistry  Researcher  2020 - 2023  35 
19.  50950  PhD Martin Rozman  Chemistry  Researcher  2020  43 
20.  38443  PhD Tina Šutar  Biotechnology  Researcher  2020 
21.  01324  PhD Iztok Takač  Human reproduction  Researcher  2022 - 2023  916 
22.  50193  Matic Tement  Medical sciences  Researcher  2022 - 2023 
23.  26203  PhD Tomaž Velnar  Neurobiology  Researcher  2020 - 2021  410 
24.  56586  Daša Zajc  Chemical engineering  Researcher  2022 - 2023 
25.  55216  Klara Žvab  Chemical engineering  Researcher  2022 
Organisations (4)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0794  University of Maribor, Faculty of Chemistry and Chemical Engineering  Maribor  5089638012  13,143 
2.  0795  University ob Maribor, Faculty of mechanical engineering  Maribor  5089638010  24,035 
3.  1540  University of Nova Gorica  Nova Gorica  5920884000  14,253 
4.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  16,626 
Abstract
The unprecedented ageing of the world’s population, along with the growing prevalence of obesity have accelerated the need for medical implants that started to dominate global healthcare costs. For this reason, high performance implantable biomaterials are in extremely high demand. In reality, not even an ideal artificial material can completely fulfill the characteristics of the human tissues and can only be a compromise, which is why all implanted medical devices suffer from recognized risks of “device-related” infections. Developing strategies and solutions to avoid or minimize undesired side effects in the use of medical implants is still a partially unsolved challenge. The ultimate goal is that the recognition of the implant as a foreign body is impaired, usually by a careful choice of the external layer, thus minimizing the initial inflammatory cell response. The objective of this project proposal is to develop novel bioactive multifunctional coatings on 3D-printed orthopedic implants. These complex coatings will be based on a combination of naturally occurring biocompatible polysaccharides to increase the osseointegration of implants and to provide additional (bio)functionality for incorporation of various therapeutic agents, namely antibiotic(s), immunomodulator(s), and anticoagulant(s). Such combination of therapeutic agents will therefore enable tissue integration, prevent infections, and provide local thromboprophylaxis, while promoting implant’s osseointegration, durability, and corrosion resistance. The developed solution will enable “all-in-one” treatment, and more importantly, extend durability of implanted materials, leading to a decrease in revision surgeries and thereby a decrease in morbidity and mortality. In order to achieve the presented objective, profound insight of the interaction phenomena between the functionalized substrate material, the (active) multifunctional coating and the biological environment is essential. This can only be accomplished by the use of state-of-the-art interdisciplinary characterization techniques and approaches. Particularly, knowledge of interaction phenomena that enable reverse manipulation and optimization of the coatings and substrates, in order to achieve the desired functional and structural properties of the final products.
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