Projects / Programmes
Mozgansko zilna reaktivnost in delovanje avtonomnega zivcevja pri cloveku v normalnih in patoloskih razmerah (Slovene)
| Code |
Science |
Field |
Subfield |
| 3.03.00 |
Medical sciences |
Neurobiology |
|
(a) transcranial doppler sonography, migraine, diabetes mellitus, autonomic neurocardiology (b) acute ishcemic stroke, autonomic nervous system, neuricardiology
Researchers (7)
Organisations (1)
Abstract
a)
With cerebrovascular reactivity we can, by using various physological stimuli, assess the functioning of different parts of regulation of cerebrovascular blood flow. Using the visual stimulus we can assess the metabolic regulation or function of neurovascular correlation. Using the head-up tilt test we could control the symphatetic function in big cerebral arteries; by inhalation of 5% CO2 gas mixture and intravenous injection of L-arginine we could assess the NO system. By determining cerebrovascular reactivity (CVR) we could estimate the function of nerovascular relations in patients with migraine and cerebral autoregulation in diabetic patients with autonomic neuropathy and find the possible dysfunction of NO system.
b)
The role of autonomic nervous system in younger patients who suffered an ischemic stroke is not completly clarified yet. The studies on that field have been scare . Due to propositions, variability in autonomic nervous system activity may largely contribute to development of brain infarction, most probably due to its influence on brain arteries reactivity. The autonomic nervous system reactivity in younger patients is more pronounced than in older ones.
We intend to clarify the role of autonomic nervous system in young stroke patients by using neurocardiologic tests, while localisation and/or extent of infarction will be evalueted by MRI.
