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Projects / Programmes source: ARIS

Vascularization and vascular effects as predictive factors for local ablative techniques

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
Tumor vasculature, blood flow, oxygenation, non-invasive imaging, spectral imaging, thermographic imaging, laser speckle imaging, radiotherapy, electrochemotherapy, head and neck tumors, mouse tumor models, veterinary oncology
Evaluation (rules)
source: COBISS
Points
18,214.6
A''
1,152.32
A'
6,411.16
A1/2
10,149.38
CI10
29,992
CImax
2,035
h10
75
A1
58.79
A3
60.37
Data for the last 5 years (citations for the last 10 years) on February 21, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender, archive )
Database Linked records Citations Pure citations Average pure citations
WoS  1,513  36,745  31,439  20.78 
Scopus  1,498  43,571  37,512  25.04 
Researchers (57)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  33434  Marko Boc  Medical sciences  Researcher  2021 - 2024  196 
2.  39650  Nina Boc  Oncology  Researcher  2021 - 2024  91 
3.  51848  PhD Tim Božič  Medical sciences  Researcher  2021 - 2024  46 
4.  35354  PhD Andreja Brožič  Oncology  Researcher  2021 - 2024  40 
5.  14575  PhD Maja Čemažar  Oncology  Researcher  2021 - 2024  1,408 
6.  29519  PhD Rok Dolenec  Physics  Researcher  2021 - 2024  86 
7.  17172  PhD Ibrahim Edhemović  Oncology  Researcher  2021 - 2024  187 
8.  36115  PhD Gorana Gašljević  Medical sciences  Researcher  2021 - 2024  210 
9.  17569  PhD Mitja Gombač  Veterinarian medicine  Researcher  2021 - 2024  199 
10.  21329  PhD Alenka Grošel  Oncology  Researcher  2021 - 2022  77 
11.  36605  PhD Aleš Grošelj  Oncology  Researcher  2021 - 2024  150 
12.  38482  PhD Blaž Grošelj  Medical sciences  Researcher  2021 - 2024  70 
13.  12628  PhD Rok Hren  Systems and cybernetics  Researcher  2022 - 2024  253 
14.  56377  Črt Jamšek  Oncology  Researcher  2023 - 2024 
15.  34856  PhD Klemen Jenko  Oncology  Researcher  2021 - 2024  123 
16.  15737  PhD Robert Jeraj  Physics  Researcher  2021 - 2024  550 
17.  33227  PhD Tanja Jesenko  Oncology  Researcher  2021 - 2024  164 
18.  28272  Vijoleta Kaluza  Oncology  Researcher  2021 - 2024 
19.  28387  PhD Urška Kamenšek  Oncology  Researcher  2021 - 2024  184 
20.  51873  Urša Kešar  Medical sciences  Junior researcher  2021 - 2024  14 
21.  36366  PhD Špela Kos  Medical sciences  Researcher  2021 - 2022  81 
22.  16229  PhD Viljem Kovač  Medical sciences  Researcher  2021 - 2024  297 
23.  19058  PhD Simona Kranjc Brezar  Medical sciences  Researcher  2021 - 2024  312 
24.  36681  PhD Martina Krofič Zel  Veterinarian medicine  Researcher  2021 - 2024  23 
25.  54178  Uroš Kuhar  Medical sciences  Researcher  2021 - 2024 
26.  36367  PhD Urša Lampreht Tratar  Oncology  Researcher  2021 - 2024  120 
27.  53564  Kristina Levpušček  Medical sciences  Junior researcher  2021 - 2022  14 
28.  39122  PhD Barbara Lisec  Medical sciences  Junior researcher  2021 - 2022  23 
29.  32175  PhD Boštjan Markelc  Medical sciences  Researcher  2021 - 2024  212 
30.  24570  PhD Maja Marolt Mušič  Oncology  Researcher  2021 - 2024  194 
31.  31530  PhD Urška Matkovič  Medical sciences  Researcher  2021  71 
32.  22288  PhD Matija Milanič  Physics  Researcher  2021 - 2024  239 
33.  39087  PhD Nina Milevoj  Veterinarian medicine  Researcher  2021 - 2022  54 
34.  20052  PhD Irena Oblak  Oncology  Researcher  2021 - 2024  299 
35.  34373  PhD Maša Omerzel  Medical sciences  Researcher  2022 - 2024  194 
36.  36119  Maja Ota  Medical sciences  Researcher  2021 - 2024 
37.  20054  MSc Marija Snežna Paulin Košir  Oncology  Researcher  2021 - 2024  45 
38.  24507  PhD Darja Pavlin  Veterinarian medicine  Researcher  2021 - 2024  160 
39.  24299  PhD Barbara Perić  Oncology  Researcher  2021 - 2024  153 
40.  38481  Gaber Plavc  Oncology  Researcher  2021 - 2024  31 
41.  25588  PhD Tanja Plavec  Veterinarian medicine  Researcher  2023 - 2024  132 
42.  34336  PhD Andrej Renčelj  Medical sciences  Researcher  2021 - 2022  22 
43.  50670  PhD Luka Rogelj  Physics  Junior researcher  2021 - 2022  29 
44.  08800  PhD Gregor Serša  Oncology  Head  2021 - 2024  1,494 
45.  27760  PhD Urban Simončič  Physics  Researcher  2021 - 2024  118 
46.  12250  PhD Marko Snoj  Oncology  Researcher  2021 - 2024  195 
47.  39233  PhD Jošt Stergar  Physics  Researcher  2021 - 2022  62 
48.  14576  PhD Primož Strojan  Oncology  Researcher  2021 - 2024  801 
49.  21552  PhD Andrej Studen  Physics  Researcher  2021 - 2024  129 
50.  18884  PhD Tanja Švara  Veterinarian medicine  Researcher  2021 - 2024  223 
51.  54831  Tadej Tomanič  Physics  Junior researcher  2021 - 2024  25 
52.  33348  PhD Katerina Tomsič  Veterinarian medicine  Researcher  2021 - 2024  44 
53.  13328  PhD Nataša Tozon  Veterinarian medicine  Researcher  2021 - 2024  383 
54.  21698  MSc Ilija Vojvodić  Systems and cybernetics  Researcher  2021 - 2024  11 
55.  36203  Zvezdana Vukmirović  Medical sciences  Researcher  2021 - 2024 
56.  51204  Miha Zabret  Cardiovascular system  Researcher  2021 - 2024 
57.  37534  PhD Katarina Žnidar  Medical sciences  Researcher  2021 - 2024  69 
Organisations (4)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,338 
2.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,282 
3.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  10,687 
4.  1554  University of Ljubljana, Faculty of Mathematics and Physics  Ljubljana  1627007  33,794 
Abstract
Vascularization of tumors and vascular effects of local ablative techniques in treatment of cancer have been extensively investigated, but available tools have several drawbacks, i.e. either being very localized, or lack resolution or use radioactive substances. With advent and development of optical techniques, several tools have been developed that can evaluate the vasculature, vascular perfusion and even several metabolic parameters. At the current stage, these techniques need integration into non-invasive multiparametric investigation of tumors. In this project, we will integrate spectral, laser speckle and thermal (SLST) imaging into one compact system and translate its use for the evaluation of vascularization of different tumor types. First, we intend to adapt the system for imaging of cutaneous tumors as well as mucosal tumors where an endoscopy-based system will be developed. Next, we will implement this method, first to analyze the vascularization pattern of different tumor histotypes. The SLST imaging and analysis of tumors will be implemented in experimental tumors as well as on tumors in human and veterinary oncology. This will give rise to a dendrogram based on tumor type specific descriptors. Second, we will implement SLST imaging and analysis to determine vascular effects of ablative techniques, such as radiotherapy and electrochemotherapy. Analysis will be done in timely intervals before and after treatment, again, of experimental tumors as well as on tumors in human and veterinary oncology. The acquired data, integrated quantitative analysis, and comparison of the data will enable the determination of the vascular characteristics and vascular effects of radiotherapy or electrochemotherapy. Based on the analyses we could establish that SLST analysis of tumors provides parameters that would be potential predictive factors for the ablative techniques.
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