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Projects / Programmes source: ARRS

Medical Physics

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Periods
January 1, 2022 - December 31, 2027
Research activity

Code Science Field Subfield
1.02.00  Natural sciences and mathematics  Physics   
3.04.00  Medical sciences  Oncology   

Code Science Field
1.03  Natural Sciences  Physical sciences 
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
Medical physics, Imaging, Therapy, Modelling
Evaluation (rules)
source: COBISS
Points
10,271.92
A''
1,988.05
A'
3,615.62
A1/2
6,152.56
CI10
13,751
CImax
1,901
h10
50
A1
35.25
A3
14.52
Data for the last 5 years (citations for the last 10 years) on June 2, 2023; A3 for period 2017-2021
Data for ARRS tenders ( 04.04.2019 – Programme tender , archive )
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Database Linked records Citations Pure citations Average pure citations
WoS  879  15,167  13,669  15.55 
Scopus  803  18,371  16,578  20.65 
Researchers (33)
no. Code Name and surname Research area Role Period No. of publications
1.  34576  PhD Rok Berlot  Medical sciences  Researcher  2022 - 2023  98 
2.  15973  PhD Božidar Casar  Natural sciences and mathematics  Researcher  2022 - 2023  124 
3.  57137  PhD Marija Delić  Natural sciences and mathematics  Researcher  2022 - 2023  0 
4.  29519  PhD Rok Dolenec  Natural sciences and mathematics  Researcher  2022 - 2023  84 
5.  54651  Živa Drakulić  Medical sciences  Junior researcher  2022 - 2023  0 
6.  11039  PhD Simona Gaberšček  Medical sciences  Researcher  2022 - 2023  440 
7.  33876  Luka Jensterle  Medical sciences  Technician  2022 - 2023  40 
8.  15737  PhD Robert Jeraj  Natural sciences and mathematics  Principal Researcher  2022 - 2023  545 
9.  53651  Žan Klaneček  Natural sciences and mathematics  Junior researcher  2022 - 2023  18 
10.  30072  PhD Maja Kojović  Medical sciences  Researcher  2022 - 2023  125 
11.  23364  PhD Petra Kolenc  Natural sciences and mathematics  Researcher  2022 - 2023  130 
12.  32227  PhD Dimitrij Kuhelj  Medical sciences  Researcher  2022 - 2023  367 
13.  22346  PhD Luka Ležaič  Medical sciences  Researcher  2022 - 2023  228 
14.  16183  PhD Mateja Logar  Medical sciences  Researcher  2022 - 2023  232 
15.  09757  PhD Matjaž Lukač  Natural sciences and mathematics  Researcher  2022 - 2023  175 
16.  22288  PhD Matija Milanič  Natural sciences and mathematics  Researcher  2022 - 2023  219 
17.  55932  Matic Orehar  Natural sciences and mathematics  Junior researcher  2022 - 2023  2 
18.  51885  Matej Perovnik  Medical sciences  Researcher  2022 - 2023  77 
19.  12531  PhD Primož Peterlin  Medical sciences  Researcher  2022 - 2023  130 
20.  51913  PhD Gašper Razdevšek  Natural sciences and mathematics  Junior researcher  2022  10 
21.  50670  PhD Luka Rogelj  Natural sciences and mathematics  Researcher  2022  28 
22.  27760  PhD Urban Simončič  Natural sciences and mathematics  Researcher  2022 - 2023  102 
23.  39233  PhD Jošt Stergar  Natural sciences and mathematics  Researcher  2022 - 2023  52 
24.  55933  Katja Strašek  Natural sciences and mathematics  Junior researcher  2022 - 2023  4 
25.  21552  PhD Andrej Studen  Natural sciences and mathematics  Researcher  2022 - 2023  116 
26.  27754  PhD Barbara Šegedin  Medical sciences  Researcher  2022 - 2023  188 
27.  53652  Eva Štokelj  Natural sciences and mathematics  Junior researcher  2022 - 2023  16 
28.  54831  Tadej Tomanič  Natural sciences and mathematics  Junior researcher  2022 - 2023  17 
29.  24691  PhD Petra Tomše  Medical sciences  Researcher  2022 - 2023  119 
30.  15442  PhD Maja Trošt  Medical sciences  Researcher  2022 - 2023  440 
31.  36913  PhD Damijan Valentinuzzi  Natural sciences and mathematics  Researcher  2022 - 2023  28 
32.  21746  PhD Martina Vrankar  Medical sciences  Researcher  2022 - 2023  120 
33.  20484  PhD Katja Zaletel  Medical sciences  Researcher  2022 - 2023  411 
Organisations (4)
no. Code Research organisation City Registration number No. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  85,820 
2.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  14,551 
3.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  73,855 
4.  1554  University of Ljubljana, Faculty of Mathematics and Physics  Ljubljana  1627007  32,001 
Abstract
Medical physics is an interdisciplinary research field aiming at development of novel applications of physical processes and techniques in various fields of medicine. Medical physics has had and continues to have a profound impact on the practice of medicine by developing improved imaging and treatment technologies, and by helping to advance our understanding of the complexity of the disease. As such, medical physics is intimately connected to medicine, which is experiencing a dramatic shift from acute to chronic disease. This shift has resulted in (1) diagnostic procedures that are becoming more comprehensive, (2) therapies that are becoming more personalized and (3) better understanding of incredible complexity of various diseases, which indirectly impacts priorities for medical physics as well. The Medical Physics Research Program (MPRP) is structured around these three key challenges, which also represent the main programmatic pillars: (1) MPRP-Imaging (2) MPRP-Therapy (3) MPRP-Modeling Within (1) MPRP-Imaging we are developing novel, more sensitive and more reliable imaging technologies, as well as innovative, quantitative imaging biomarkers that can reliably diagnose disease or predict patient outcome in cancer, neurodegenerative and inflammatory diseases. Within (2) MPRP-Therapy we are developing more effective immunotherapeutic, theranostics and localized image-guided treatment strategies that can combat incredible inter-lesion response heterogeneity observed in state-of-the-art precision medicine. Within (3) MPRP-Modelling we are developing novel methods in big data analytics that can account for safety-critical scenarios associated with clinical decisions and advanced transport models that can address complexity of particle interactions with specific tissues. We have assembled unique interdisciplinary MPRP research team that includes members from the major Slovenian university (University of Ljubljana), the major research institute (Jožef Stefan Institute), the main tertiary hospital (University Medical Centre Ljubljana) and the comprehensive cancer center (Institute of Oncology). MPRP research team provides key platform for: o Translation of fundamental physics research into clinical practice o Translation of cutting edge medical technologies from academia to commercialization o Education of Medical Physics and associated sciences and professions o Outreach informing general public about advanced medical physics sciences and technologies As such, Medical Physics Research Program has high propulsion and relevance for local economy and health care, which is also reflected in the popularity of the Medical Physics training, education and outreach.
Significance for science
Extremely dynamic progress in medicine and life sciences over the past decades has also fueled very rapid and propulsive research in medical physics. While medicine cannot prevent and cure many diseases, it is able to manage most severe acute conditions by turning them into long-term chronic conditions. Given this dramatic shift from acute to chronic diseases, the strategies for prevention and treatment are beginning to change. This shift has resulted in (1) diagnostic procedures that are becoming more comprehensive, utilizing a variety of diagnostic tools, from molecular imaging procedures to various molecular biomarkers, like genetic and molecular profiling. Similarly, (2) therapies are becoming more personalized, addressing specifics and heterogeneity of the disease in each patient. Finally, rapid progress in life sciences, particularly cell and molecular biology, has started to (3) uncover the incredible complexity of diseases, which we barely started to understand. The Medical Physics Research Program (MPRP) is structured around these key challenges, which also represent the three key program pillars: (1) MPRP-Imaging (2) MPRP-Therapy (3) MPRP-Modeling MPRP projects within these pillars are driven by needs identified primarily via our strong relationships with clinicians from Slovenia and internationally. As addressing these pillars requires an inherently interdisciplinary approach, our program involves active collaborations between physicists, oncologists, neurologists, radiologists, nuclear medicine physicians, pharmacologists, biologists and computer scientists. Within MPRP-Imaging we are developing novel, more sensitive and more reliable imaging technologies (e.g., advanced optical imaging systems, advanced detectors for PET) that can open opportunities for novel imaging applications. We are also developing innovative, quantitative imaging biomarkers that can reliably diagnose disease or predict patient outcome (e.g., early cancer detection, early detection and identification of neurodegenerative brain disorders). Within MPRP-Therapy we are developing more effective immunotherapeutic strategies and are targeting resistance with innovative localized therapies to combat incredible treatment response heterogeneity observed in precision medicine. We are also developing methodologies for image-guided interventions, including in the emerging fields of theranostics and image-guided proton therapy. Within MPRP-Modelling we are developing novel methods of big data analytics that account for safety-critical scenarios associated with clinical decisions. Similarly, we are addressing the complexity of light interaction with specific tissues and organs due to the complex structure on different scales and incomplete knowledge of their optical properties with developments of novel transport models and approximations.
Significance for the country
Life expectancy has markedly increased due to the progress made in reducing death from acute conditions. However, advances in medicine indirectly led to a major rise in the burden of chronic long-term conditions. It is estimated that 75 % of today's healthcare expenditures are related to chronic diseases. Cancer and neurodegenerative brain disorders contribute a lion's share to these expenditures. Worldwide, there were approximately 19 million people who had cancer diagnosed in 2020. There are additional 50 million people who live with dementia and more than 10 million with parkinsonism. The financial burden of these diseases in EU is close to 2 % of the GDP with €126 billion expenditure for cancer, €105.2 billion for dementia and €13.9 billion for parkinsonism. Medical Physics Research Program (MPRP) is extremely ambitious in its efforts to address major socio-economic challenges in healthcare in Slovenia, EU and worldwide, focusing in each of the three MPRP research pillars on: (1) Early and more accurate diagnosis of cancer, neurodegenerative disorders and inflammatory diseases by developing improved imaging technologies and novel Quantitative Imaging Biomarkers (within MPRP-Imaging). (2) Personalized medicine accounting for biological heterogeneity by developing innovative treatment strategies spanning from immunotherapies, theranostics and image-guided particle interventions (within MPRP-Therapy). (3) Developing disease models to allow a better understanding of the fundamental causes of diseases and response to treatment, including novel approaches to big data analytics (within MPRP-Modeling). MPRP provides the main interdisciplinary platform for translation of fundamental physics discoveries into clinical practice. The MPRP research team includes members from the major Slovenian university (University of Ljubljana), the major research institute (Jožef Stefan Institute), the main tertiary hospital (University Medical Centre Ljubljana) and the comprehensive cancer center (Institute of Oncology). The broad socio-economic relevance of the MPRP research is directly underlined by one of the EU "Horizons 2020" priorities: "Clinical trial(s) supporting proof of concept in humans to assess the potential clinical efficacy of the novel therapeutic concept(s) and/or optimization of available therapies." MPRP provides the main organized effort for translation of the cutting edge medical technologies from academia to commercialization. The MPRP has an extensive track record of both successful academic-industrial partnerships, as well as commercialization of innovative technologies. Part of our success is driven by direct integration of industrial research within MPRP. We have formed a close partnership with a number of Slovenian and international companies, which help translating our research findings into commercial products. MPRP provides the main research environment for supporting education of Medical Physics and development of the Medical Physics profession in Slovenia. The Medical Physics program at the Faculty of Mathematics and Physics at the University of Ljubljana (only Medical Physics program in Slovenia) is highly popular by physics students and is almost exclusively supported by the MPRP members. The seamless integration of medical researchers and practicing physicians in the MPRP emphasize the practical relevance of the Medical Physics program and underline critical aspects of interdisciplinary research. Similarly, the MPRP provides a perfect ground for training of physicians in physical sciences, as many MPRP members are involved in teaching at the Faculty of Medicine at the University of Ljubljana. MPRP provides the main public forum for educating general public about advanced medical physics science through outreach efforts. MPRP is extensively engaged in a range of outreach efforts, participating in some of the main Slovenian public forums for promoting science. We are organizing a number of dedicated outreach events, such as a unique national student competition in development of novel data analytics methods in medicine. These events help attracting the brightest students into the field of medical physics, promoting medical physics as an attractive career option, and serve as the forum for broader education of general public about scientific and technological advances in medical physics.
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